Determination of bismuth in pharmaceutical products using liquid-liquid extraction in a flow injection system

被引：38
|
作者：
Alonso, A [1 ]
Almendral, MJ [1 ]
Báez, MD [1 ]
Porras, MJ [1 ]
Lávin, FL [1 ]
de María, CG [1 ]
机构：
[1] Univ Salamanca, Fac Chem, Dept Quim Analit Nutr & Bromatol, E-37008 Salamanca, Spain
来源：
ANALYTICA CHIMICA ACTA | 2000年 / 408卷 / 1-2期
关键词：
liquid-liquid extraction; flow injection; bismuth; ion-pair; pharmaceuticals;
D O I：
10.1016/S0003-2670(99)00768-0
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A flow injection procedure for the determination of bismuth in pharmaceutical products is described. The procedure is based on the formation of an ion-pair between tetraphenylarsonium and the tetraiodobismuthate(III) anion. This ion-pair is extracted with chloroform and the absorbance of the organic phase is measured at 363 or 505 nm. The detection Limit (3 x baseline s.d.) is 1.5 x 10(-6) M (35 ng). The proposed procedure has a relative standard deviation of 1.6% (3.0 x 10(-5) M, n = 12), a linear application range between 2.3 x 10(-6) and 1.5 x 10(-4) M and a sampling frequency of 40 h(-1). Under the proposed working conditions, only Pd(II), Pt(IV) and Au(III) interfere. (C) 2000 Elsevier Science B.V. All rights reserved.
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页码：129 / 133
页数：5
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