Lymphocyte Functions in Patients with Chronic Granulomatous Disease and Carrier Individuals

被引:0
作者
Ogulur, Ismail [1 ]
Baris, Ezgi [1 ]
Kiykim, Ayca [1 ]
Baser, Dilek [1 ]
Akgun, Gamze [1 ]
Ozen, Ahmet [1 ]
Baris, Safa [1 ]
Karakoc-Aydiner, Elif [1 ]
机构
[1] Marmara Univ, Tip Fak, Pediat Allerji & Immunol Bilim Dali, Istanbul, Turkey
来源
TURKISH JOURNAL OF IMMUNOLOGY | 2019年 / 7卷 / 02期
关键词
Chronic granulomatous disease; lymphocyte; proliferation; Treg; intracellular cytokines; X-LINKED CARRIERS; REGULATORY T-CELLS; MANIFESTATIONS;
D O I
10.25002/tji.2019.1111
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Introduction: Chronic granulomatous disease (CGD) is classically known as phagocytic system disease. However, in recent years, the observation of the development of autoimmunity, colitis-like findings during follow-up has suggested that the acquired immune system may also be defective. The aim of this project is to investigate the percent of T and B lymphocytes, and function of T lymphocytes in patients with CGD and carriers. Material and Methods: Eleven patients followed for CGD (3 X-CGD, 8 OR-CGD) in our clinic and 6 carrier mothers of OR-CGD were included into the study. The percentages of lymphocytes and their subtypes, lymphocyte proliferation, regulator T cell (Treg), intracellular cytokine content of patients with CDC and carriers we re determined in comparison to healthy controls. Results: There was no statistically significant difference in percentages of T cell, B cell and NK cell and subtypes of T and B cells in the mothers of patients compared to age marched healthy controls. The percentage of naive B cells was significantly higher in the patients with CGD compared to those of healthy subjects (p<0.001). There were no significant differences in lymphocyte proliferation, Treg cell percentage, intracellular IL-17 levels, but IFN-gamma levels were significantly increased in both patients with CDG (p=0.030) and carriers (p=0.038) when compared with age-matched healthy controls. Conclusion: Increased naive B cells were found in CGD patients. High levels of IFN-gamma in patients and carriers need to be further evaluated by further studies. In addition, the normal percentages of Treg and IL-21 in the carriers as in healthy subjects may be offered as the protective mechanism for autoimmunity.
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页码:93 / 101
页数:9
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