Centromeric alpha-satellite DNA at euchromatin/heterochromatin boundary of human chromosome 21

被引:0
作者
Mashkova, TD
Tyumeneva, IG
Zinoveva, OL
Romanova, LY
Jabs, E
Aleksandrov, IA
机构
[1] RUSSIAN ACAD MED SCI,RUSSIAN CTR MENTAL HLTH,MOSCOW 113152,RUSSIA
[2] JOHNS HOPKINS UNIV,SCH MED,BALTIMORE,MD
关键词
alpha-satellite DNA; heterochromatin; euchromatin; chromosome; 21; dispersed repeats;
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A clone covering the euchromatin/heterochromatin boundary was isolated from a cosmid library specific for the human chromosome 21. This DNA contained a long block of the centromeric a-satellite DNA, unique nucleotide sequences, and dispersed Alu and L1 repeats. The a-satellite block constituted about a half of total length (about 45 kb) of the cloned DNA. It was adjacent to, but not overlapping with the nonsatellite region. The border between alphoid and nonalphoid domains was found in the longest subclone of 11 kb. This subclone was completely sequenced, and the sequence analyzed. The primary structure of an alphoid DNA of about 12 kb was shown to be different from the known chromosome 21-specific alphoid families and from the other described sequences. It was attributed to the suprachromosomal family 4 characterized by monomeric organization of the ancestral repeat. This alphoid DNA had no higher-order repeated structures typical of satellites. Insertions of one Alu repeat and three truncated L1 repeats were detected. One of the latter was flanked by direct repeats, as common for the mobile elements of the human genome.
引用
收藏
页码:617 / 625
页数:9
相关论文
共 39 条
  • [1] CHROMOSOME-SPECIFIC ALPHA-SATELLITES - 2 DISTINCT FAMILIES ON HUMAN CHROMOSOME-18
    ALEXANDROV, IA
    MASHKOVA, TD
    AKOPIAN, TA
    MEDVEDEV, LI
    KISSELEV, LL
    MITKEVICH, SP
    YUROV, YB
    [J]. GENOMICS, 1991, 11 (01) : 15 - 23
  • [2] ALEXANDROV IA, 1993, NUCLEIC ACIDS RES, V21, P2209
  • [3] ALEXANDROV IA, 1993, J MOL BIOL, V231, P515
  • [4] ALTSCHUL SF, 1990, J MOL BIOL, V215, P403, DOI 10.1006/jmbi.1990.9999
  • [5] [Anonymous], MOBILE DNA
  • [6] THE CENTROMERIC K-TYPE REPEAT AND THE CENTRAL CORE ARE TOGETHER SUFFICIENT TO ESTABLISH A FUNCTIONAL SCHIZOSACCHAROMYCES-POMBE CENTROMERE
    BAUM, M
    NGAN, VK
    CLARKE, L
    [J]. MOLECULAR BIOLOGY OF THE CELL, 1994, 5 (07) : 747 - 761
  • [7] HOMOLOGOUS ALPHA-SATELLITE SEQUENCES ON HUMAN ACROCENTRIC CHROMOSOMES WITH SELECTIVITY FOR CHROMOSOMES 13, 14 AND 21 - IMPLICATIONS FOR RECOMBINATION BETWEEN NONHOMOLOGUES AND ROBERTSONIAN TRANSLOCATIONS
    CHOO, KH
    VISSEL, B
    BROWN, R
    FILBY, RG
    EARLE, E
    [J]. NUCLEIC ACIDS RESEARCH, 1988, 16 (04) : 1273 - 1283
  • [8] CONTINUUM OF OVERLAPPING CLONES SPANNING THE ENTIRE HUMAN CHROMOSOME-21Q
    CHUMAKOV, I
    RIGAULT, P
    GUILLOU, S
    OUGEN, P
    BILLAUT, A
    GUASCONI, G
    GERVY, P
    LEGALL, I
    SOULARUE, P
    GRINAS, L
    BOUGUELERET, L
    BELLANNECHANTELOT, C
    LACROIX, B
    BARILLOT, E
    GESNOUIN, P
    POOK, S
    VAYSSEIX, G
    FRELAT, G
    SCHMITZ, A
    SAMBUCY, JL
    BOSCH, A
    ESTIVILL, X
    WEISSENBACH, J
    VIGNAL, A
    RIETHMAN, H
    COX, D
    PATTERSON, D
    GARDINER, K
    HATTORI, M
    SAKAKI, Y
    ICHIKAWA, H
    OHKI, M
    LEPASLIER, D
    HEILIG, R
    ANTONARAKIS, S
    COHEN, D
    [J]. NATURE, 1992, 359 (6394) : 380 - 387
  • [9] ISOLATION OF A YEAST CENTROMERE AND CONSTRUCTION OF FUNCTIONAL SMALL CIRCULAR CHROMOSOMES
    CLARKE, L
    CARBON, J
    [J]. NATURE, 1980, 287 (5782) : 504 - 509
  • [10] SEQUENCE HETEROGENEITY WITHIN THE HUMAN ALPHOID REPETITIVE DNA FAMILY
    DEVILEE, P
    SLAGBOOM, P
    CORNELISSE, CJ
    PEARSON, PL
    [J]. NUCLEIC ACIDS RESEARCH, 1986, 14 (05) : 2059 - 2073