Triacylglycerol hydrolase: role in intracellular lipid metabolism

被引：101
作者：
Dolinsky, VW
Gilham, D
Alam, M
Vance, DE
Lehner, R [1 ]
机构：
[1] Univ Alberta, Heritage Med Res Ctr 328, Dept Pediat, CIHR Grp Mol & Cell Biol Lipids, Edmonton, AB T6G 2S2, Canada
[2] Univ Alberta, Heritage Med Res Ctr 328, Dept Cell Biol, CIHR Grp Mol & Cell Biol Lipids, Edmonton, AB T6G 2S2, Canada
[3] Univ Alberta, Heritage Med Res Ctr 328, Dept Biochem, CIHR Grp Mol & Cell Biol Lipids, Edmonton, AB T6G 2S2, Canada
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2004年 / 61卷 / 13期
关键词：
lipase; carboxylesterase; triacylglycerol; VLDL; liver; adipose; atherosclerosis;
D O I：
10.1007/s00018-004-3426-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent scientific advances have revealed the identity of several enzymes involved in the synthesis, storage and catabolism of intracellular neutral lipid storage droplets. An enzyme that hydrolyzes stored triacylglycerol (TG), triacylglycerol hydrolase (TGH), was purified from porcine, human and murine liver microsomes. In rodents, TGH is highly expressed in liver as well as heart, kidney, small intestine and adipose tissues, while in humans TGH is mainly expressed in the liver, adipose and small intestine. TGH localizes to the endoplasmic reticulum and lipid droplets. The TGH genes are located within a cluster of carboxylesterase genes on human and mouse chromosomes 16 and 8, respectively. TGH hydrolyzes stored TG, and in the liver, the lipolytic products are made available for VLDL-TG synthesis. Inhibition of TGH activity also inhibits TG and apolipoprotein B secretion by primary hepatocytes. A role for TGH in basal TG lipolysis in adipocytes has been proposed. TGH expression and activity is both developmentally and hormonally regulated. A model for the function of TGH is presented and discussed with respect to tissue specific functions.
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页码：1633 / 1651
页数：19
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