Biological Roles Of Neutrophil-Derived Granule Proteins and Cytokines

被引：180

作者：

Cassatella, Marco Antonio ^{[1
]}

Ostberg, Nataliya K. ^{[2
,3
]}

Tamassia, Nicola ^{[1
]}

Soehnlein, Oliver ^{[2
,3
,4
,5
]}

机构：

[1] Univ Verona, Sect Gen Pathol, Dept Med, Verona, Italy

[2] Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden

[3] Karolinska Inst, Dept Med, Stockholm, Sweden

[4] Klinikum LMU, Inst Cardiovasc Prevent IPEK, Munich, Germany

[5] German Ctr Cardiovasc Res DZHK, Munich, Germany

来源：

TRENDS IN IMMUNOLOGY | 2019年 / 40卷 / 07期

关键词：

NF-KAPPA-B; PAPILLON-LEFEVRE SYNDROME; PROTEOMIC ANALYSIS; GENE-EXPRESSION; ACTIVATED NEUTROPHILS; TRANSCRIPTION FACTORS; SECRETORY VESICLES; PLASMA-MEMBRANE; MYELOID CELLS; C/EBP-ALPHA;

D O I：

10.1016/j.it.2019.05.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neutrophils, the most abundant white blood cells in human circulation, entertain intense interactions with other leukocyte subsets, platelets, and stromal cells. Molecularly, such interactions are typically communicated through proteins generated during granulopoiesis, stored in granules, or produced on demand. Here, we provide an overview of the mammalian regulation of granule protein production in the bone marrow and the de novo synthesis of cytokines by neutrophils recruited to tissues. In addition, we discuss some of the known biological roles of these protein messengers, and how neutrophil-borne granule proteins and cytokines can synergize to modulate inflammation and tumor development. Decoding the neutrophil interactome is important for therapeutically neutralizing individual proteins to putatively dampen inflammation, or for delivering modified neutrophil-borne proteins to boost host defense.

引用

页码：648 / 664

页数：17

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