Biological Roles Of Neutrophil-Derived Granule Proteins and Cytokines

被引：180

作者：

Cassatella, Marco Antonio ^{[1
]}

Ostberg, Nataliya K. ^{[2
,3
]}

Tamassia, Nicola ^{[1
]}

Soehnlein, Oliver ^{[2
,3
,4
,5
]}

机构：

[1] Univ Verona, Sect Gen Pathol, Dept Med, Verona, Italy

[2] Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden

[3] Karolinska Inst, Dept Med, Stockholm, Sweden

[4] Klinikum LMU, Inst Cardiovasc Prevent IPEK, Munich, Germany

[5] German Ctr Cardiovasc Res DZHK, Munich, Germany

来源：

TRENDS IN IMMUNOLOGY | 2019年 / 40卷 / 07期

关键词：

NF-KAPPA-B; PAPILLON-LEFEVRE SYNDROME; PROTEOMIC ANALYSIS; GENE-EXPRESSION; ACTIVATED NEUTROPHILS; TRANSCRIPTION FACTORS; SECRETORY VESICLES; PLASMA-MEMBRANE; MYELOID CELLS; C/EBP-ALPHA;

D O I：

10.1016/j.it.2019.05.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neutrophils, the most abundant white blood cells in human circulation, entertain intense interactions with other leukocyte subsets, platelets, and stromal cells. Molecularly, such interactions are typically communicated through proteins generated during granulopoiesis, stored in granules, or produced on demand. Here, we provide an overview of the mammalian regulation of granule protein production in the bone marrow and the de novo synthesis of cytokines by neutrophils recruited to tissues. In addition, we discuss some of the known biological roles of these protein messengers, and how neutrophil-borne granule proteins and cytokines can synergize to modulate inflammation and tumor development. Decoding the neutrophil interactome is important for therapeutically neutralizing individual proteins to putatively dampen inflammation, or for delivering modified neutrophil-borne proteins to boost host defense.

引用

页码：648 / 664

页数：17

共 144 条

[1] A Neutrophil Timer Coordinates Immune Defense and Vascular Protection [J].

Adrover, Jose M. ;

del Fresno, Carlos ;

Crainiciuc, Georgiana ;

Isabel Cuartero, Maria ;

Casanova-Acebes, Maria ;

Weiss, Linnea A. ;

Huerga-Encabo, Hector ;

Silvestre-Roig, Carlos ;

Rossaint, Jan ;

Cossio, Itziar ;

Lechuga-Vieco, Ana V. ;

Garcia-Prieto, Jaime ;

Gomez-Parrizas, Monica ;

Quintana, Juan A. ;

Ballesteros, Ivan ;

Martin-Salamanca, Sandra ;

Aroca-Crevillen, Alejandra ;

Chong, Shu Zhen ;

Evrard, Maximilien ;

Balabanian, Karl ;

Lopez, Jorge ;

Bidzhekov, Kiril ;

Bachelerie, Frangoise ;

Abad-Santos, Francisco ;

Munoz-Calleja, Cecilia ;

Zarbock, Alexander ;

Soehnlein, Oliver ;

Weber, Christian ;

Ng, Lai Guan ;

Lopez-Rodriguez, Cristina ;

Sancho, David ;

Moro, Maria A. ;

Ibanez, Borja ;

Hidalgo, Andres .

IMMUNITY, 2019, 50 (02) :390-+

[2] Recruitment of classical monocytes can be inhibited by disturbing heteromers of neutrophil HNP1 and platelet CCL5 [J].

Alard, Jean-Eric ;

Ortega-Gomez, Almudena ;

Wichapong, Kanin ;

Bongiovanni, Dario ;

Horckmans, Michael ;

Megens, Remco T. A. ;

Leoni, Giovanna ;

Ferraro, Bartolo ;

Rossaint, Jan ;

Paulin, Nicole ;

Ng, Judy ;

Ippel, Hans ;

Suylen, Dennis ;

Hinkel, Rabea ;

Blanchet, Xavier ;

Gaillard, Fanny ;

D'Amico, Michele ;

von Hundelshausen, Phillipp ;

Zarbock, Alexander ;

Scheiermann, Christoph ;

Hackeng, Tilman M. ;

Steffens, Sabine ;

Kupatt, Christian ;

Nicolaes, Gerry A. F. ;

Weber, Christian ;

Soehnlein, Oliver .

SCIENCE TRANSLATIONAL MEDICINE, 2015, 7 (317)

[3] Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice [J].

Albrengues, Jean ;

Shields, Mario A. ;

Ng, David ;

Park, Chun Gwon ;

Ambrico, Alexandra ;

Poindexter, Morgan E. ;

Upadhyay, Priya ;

Uyeminami, Dale L. ;

Pommier, Arnaud ;

Kuttner, Victoria ;

Bruzas, Emilis ;

Maiorino, Laura ;

Bautista, Carmelita ;

Carmona, Ellese M. ;

Gimotty, Phyllis A. ;

Fearon, Douglas T. ;

Chang, Kenneth ;

Lyons, Scott K. ;

Pinkerton, Kent E. ;

Trotman, Lloyd C. ;

Goldberg, Michael S. ;

Yeh, Johannes T. -H. ;

Egeblad, Mikala .

SCIENCE, 2018, 361 (6409) :1353-+

[4] Lipopolysaccharide-induced gelatinase granule mobilization primes neutrophils for activation by galectin-3 and formylmethionyl-Leu-Phe [J].

Almkvist, J ;

Fäldt, J ;

Dahlgren, C ;

Leffler, H ;

Karlsson, A .

INFECTION AND IMMUNITY, 2001, 69 (02) :832-837

[5] Proteomic Analysis of Neutrophil Priming by PAF [J].

Aquino, Elaine N. ;

Neves, Anne C. D. ;

Santos, Karina C. ;

Uribe, Carlos E. ;

Souza, Paulo E. N. ;

Correa, Jose R. ;

Castro, Mariana S. ;

Fontes, Wagner .

PROTEIN AND PEPTIDE LETTERS, 2016, 23 (02) :142-151

[6] Human Neutrophils Produce CCL23 in Response to Various TLR-Agonists and TNFα [J].

Arruda-Silva, Fabio ;

Bianchetto-Aguilera, Francisco ;

Gasperini, Sara ;

Polletti, Sara ;

Cosentino, Emanuela ;

Tamassia, Nicola ;

Cassatella, Marco A. .

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2017, 7

[7] Neutrophil proteomic analysis reveals the participation of antioxidant enzymes, motility and ribosomal proteins in the prevention of ischemic effects by preconditioning [J].

Arshid, S. ;

Tahir, M. ;

Fontes, B. ;

Montero, E. F. S. ;

Castro, M. S. ;

Sidoli, S. ;

Schwammle, V. ;

Roepstorff, P. ;

Fontes, W. .

JOURNAL OF PROTEOMICS, 2017, 151 :162-173

[8] High performance mass spectrometry based proteomics reveals enzyme and signaling pathway regulation in neutrophils during the early stage of surgical trauma [J].

Arshid, Samina ;

Tahir, Muhammad ;

Fontes, Belchor ;

de Souza Montero, Edna Frasson ;

Castro, Mariana S. ;

Sidoli, Simone ;

Roepstorff, Peter ;

Fontes, Wagner .

PROTEOMICS CLINICAL APPLICATIONS, 2017, 11 (1-2)

[9] Activation of Neutrophils by the Two-Component Leukotoxin LukE/D from Staphylococcus aureus: Proteomic Analysis of the Secretions [J].

Aslam, Rizwan ;

Laventie, Benoit-Joseph ;

Marban, Celine ;

Prevost, Gilles ;

Keller, Daniel ;

Strub, Jean-Marc ;

van Dorsselaer, Alain ;

Haikel, Youssef ;

Taddei, Corinne ;

Metz-Boutigue, Marie-Helene .

JOURNAL OF PROTEOME RESEARCH, 2013, 12 (08) :3667-3678

[10] Expression and regulation of C/EBPα in normal myelopoiesis and in malignant transformation [J].

Avellino, Roberto ;

Delwel, Ruud .

BLOOD, 2017, 129 (15) :2083-2091

← 1 2 3 4 5 6 7 8 9 10 →