Role of Nutraceuticals in COVID-19 Mediated Liver Dysfunction

被引：13

作者：

Sikander, Mohammed ^{[1
,2
]}

Malik, Shabnam ^{[1
,2
]}

Rodriguez, Anyssa ^{[1
,2
]}

Yallapu, Murali M. ^{[1
,2
]}

Narula, Acharan S. ^{[3
]}

Satapathy, Sanjaya K. ^{[4
]}

Dhevan, Vijian ^{[5
]}

Chauhan, Subhash C. ^{[1
,2
]}

Jaggi, Meena ^{[1
,2
]}

机构：

[1] Univ Texas Rio Grande Valley, Sch Med, Dept Immunol & Microbiol, Mcallen, TX 78504 USA

[2] Univ Texas Rio Grande Valley, South Texas Ctr Excellence Canc Res, Sch Med, Mcallen, TX 78504 USA

[3] Narula Res LLC, 107 Boulder Bluff, Chapel Hill, NC 27516 USA

[4] Northwell Hlth, Barbara & Zucker Sch Med, Sandra Atlas Bass Ctr Liver Dis & Transplantat, Div Hepatol,Dept Internal Med, Manhasset, NY 11030 USA

[5] Univ Texas Rio Grande Valley, Sch Med, Dept Surg, Edinburg, TX 78539 USA

来源：

MOLECULES | 2020年 / 25卷 / 24期

基金：

美国国家卫生研究院;

关键词：

COVID-19; coronavirus; ACE2; hepatic dysfunctions; hepatoprotective agents; nutraceuticals; SARS-CoV-2; CICHORIUM-INTYBUS L; SILYBIN-PHOSPHATIDYLCHOLINE COMPLEX; PHYLLANTHUS-AMARUS SCHUM; SOLANUM-NIGRUM; CARBON-TETRACHLORIDE; OXIDATIVE STRESS; ANTIHEPATOTOXIC ACTIVITY; INDUCED HEPATOTOXICITY; ETHANOLIC EXTRACT; GLYCYRRHIZIC ACID;

D O I：

10.3390/molecules25245905

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

COVID-19 is known as one of the deadliest pandemics of the century. The rapid spread of this deadly virus at incredible speed has stunned the planet and poses a challenge to global scientific and medical communities. Patients with COVID-19 are at an increased risk of co-morbidities associated with liver dysfunction and injury. Moreover, hepatotoxicity induced by antiviral therapy is gaining importance and is an area of great concern. Currently, alternatives therapies are being sought to mitigate hepatic damage, and there has been growing interest in the research on bioactive phytochemical agents (nutraceuticals) due to their versatility in health benefits reported in various epidemiological studies. Therefore, this review provides information and summarizes the juncture of antiviral, immunomodulatory, and hepatoprotective nutraceuticals that can be useful during the management of COVID-19.

引用

页数：17

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