An update on the role of nanovehicles in nose-to-brain drug delivery

被引：92
作者：
Feng, Yunhai [1 ]
He, Haisheng [2 ]
Li, Fengqian [1 ]
Lu, Yi [2 ]
Qi, Jianping [2 ]
Wu, Wei [2 ]
机构：
[1] Dahua Hosp, Dept Otorhinolaryngol Head & Neck Surg, Shanghai, Peoples R China
[2] Fudan Univ, Sch Pharm, Key Lab Smart Drug Delivery MOE & PLA, Shanghai, Peoples R China
来源：
DRUG DISCOVERY TODAY | 2018年 / 23卷 / 05期
基金：
中国国家自然科学基金;
关键词：
SOLID LIPID NANOPARTICLES; INTRANASAL DELIVERY; CHITOSAN NANOPARTICLES; NASAL DELIVERY; IN-VITRO; LOADED MICROEMULSION; TRANSNASAL DELIVERY; BETA-CYCLODEXTRIN; SURFACE-CHARGE; TRANSPORT;
D O I：
10.1016/j.drudis.2018.01.005
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A quantitative analysis has cast doubt over the limited advantages provided by particles for nose-to-brain (NTB) drug delivery. Thus, it is imperative to identify the role of nanovehicles in NTB drug delivery. If nanocarriers are used merely as an option to improve various properties of the drugs or the formulations, it is difficult for them to outperform conventional formulations, such as solutions or gels. However, nanovehicles bring about special features, such as maintenance of the solubilized state of drugs, sustained or delayed release, and enhanced penetration because of surface modifications, all of which lead to enhanced NTB delivery efficiency.
引用
收藏
页码：1079 / 1088
页数：10
相关论文
共 60 条
[1]   Evidence of nose-to-brain delivery of nanoemulsions: cargoes but not vehicles [J].
Ahmad, Ejaj ;
Feng, Yunhai ;
Qi, Jianping ;
Fan, Wufa ;
Ma, Yuhua ;
He, Haisheng ;
Xia, Fei ;
Dong, Xiaochun ;
Zhao, Weili ;
Lu, Yi ;
Wu, Wei .
NANOSCALE, 2017, 9 (03) :1174-1183
[2]   Rutin-encapsulated chitosan nanoparticles targeted to the brain in the treatment of Cerebral Ischemia [J].
Ahmad, Niyaz ;
Ahmad, Rizwan ;
Naqvi, Atta Abbas ;
Alam, Md Aftab ;
Ashafaq, Mohammad ;
Samim, Mohd ;
Iqbal, Zeenat ;
Ahmad, Farhan Jalees .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2016, 91 :640-655
[3]   RETRACTED: PNIPAM nanoparticles for targeted and enhanced nose-to-brain delivery of curcuminoids: UPLC/ESI-Q-ToF-MS/MS-based pharmacokinetics and pharmacodynamic evaluation in cerebral ischemia model (Retracted Article) [J].
Ahmad, Niyaz ;
Ahmad, Iqbal ;
Umar, Sadiq ;
Iqbal, Zeenat ;
Samim, Mohd ;
Ahmad, Farhan Jalees .
DRUG DELIVERY, 2016, 23 (07) :2095-2114
[4]   Brain delivery of buspirone hydrochloride chitosan nanoparticles for the treatment of general anxiety disorder [J].
Bari, Naimat Kalim ;
Fazil, Mohammad ;
Hassan, Md Quamrul ;
Haider, Md Rafi ;
Gaba, Bharti ;
Narang, Jasjeet K. ;
Baboota, Sanjula ;
Ali, Javed .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2015, 81 :49-59
[5]   Development, characterization and nasal delivery of rosmarinic acid-loaded solid lipid nanoparticles for the effective management of Huntington's disease [J].
Bhatt, Rahul ;
Singh, Devendra ;
Prakash, Atish ;
Mishra, Neeraj .
DRUG DELIVERY, 2015, 22 (07) :931-939
[6]   Intranasal delivery of rotigotine to the brain with lactoferrin-modified PEG-PLGA nanoparticles for Parkinson's disease treatment [J].
Bi, Chenchen ;
Wang, Aiping ;
Chu, Yongchao ;
Liu, Sha ;
Mu, Hongjie ;
Liu, Wanhui ;
Wu, Zimei ;
Sun, Kaoxiang ;
Li, Youxin .
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2016, 11 :6547-6559
[7]   Quetiapine Nanoemulsion for Intranasal Drug Delivery: Evaluation of Brain-Targeting Efficiency [J].
Boche, Mithila ;
Pokharkar, Varsha .
AAPS PHARMSCITECH, 2017, 18 (03) :686-696
[8]   Nose to brain delivery in rats: Effect of surface charge of rhodamine B labeled nanocarriers on brain subregion localization [J].
Bonaccorso, A. ;
Musumeci, T. ;
Serapide, M. F. ;
Pellitteri, R. ;
Uchegbu, I. F. ;
Puglisi, G. .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2017, 154 :297-306
[9]  
Chow HHS, 1999, J PHARM SCI, V88, P754
[10]   The nasal delivery of nanoencapsulated statins - an approach for brain delivery [J].
Clementino, Adryana ;
Batger, Mellissa ;
Garrastazu, Gabriela ;
Pozzoli, Michele ;
Del Favero, Elena ;
Rondelli, Valeria ;
Gutfilen, Bianca ;
Barboza, Thiago ;
Sukkar, Maria B. ;
Souza, Sergio A. L. ;
Cantu, Laura ;
Sonvico, Fabio .
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2016, 11 :6575-6590
123456