Clinical features of primary cicatricial alopecia in Chinese patients

被引:29
作者
Qi, Shiling [1 ]
Zhao, Ying [1 ]
Zhang, Xiaoting [1 ]
Li, Shuifeng [1 ]
Cao, Hui [1 ]
Zhang, Xingqi [1 ]
机构
[1] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Dermatol, Guangzhou 510080, Guangdong, Peoples R China
关键词
Cicatricial/scarring alopecia; clinical features; dermoscopy; pathology; DIAGNOSIS; UPDATE; DERMOSCOPY;
D O I
10.4103/0378-6323.136833
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background: There have been few reports on primary cicatricial alopecias (PCR) especially from Asia (PCA). Aims: To study the clinical, pathological and dermoscopic characteristics of PCA among Chinese patients. Methods: A retrospective analysis of the clinical data of 59 patients with PCA was conducted and the dermoscopic, pathological, treatment and prognosis characteristics analyzed. Fisher's Chi-square exact test, Kruskal-Wallis and Spearman rank correlation test were performed. Results: The ratio of neutrophilic to lymphocytic cicatricial alopecias was about 1.3:1 in this group. The most frequent disorder was folliculitis decalvans. Follicular openings were absent on dermoscopy in all cases except alopecia mucinosa. Patulous follicular openings were characterisitc of alopecia mucinosa. After treatment, an increase in short vellus hairs was the earliest feature, while telangiectasia, epidermal scale, follicular hyperkeratosis, pustules and hair diameter diversity gradually decreased or even disappeared. Improvement in the areas of hair loss after treatment was seen more often in discoid lupus erythematosus, folliculitis decalvans and dissecting cellulitis than in patients with classic pseudopelade of Brocq. Nine patients (13.6%) relapsed after cessation of therapy. Female patients needed longer treatment times. Long duration, large areas of hair loss and shorter treatment courses were the major factors in relapses. Conclusions: Dermatoscopy provides a rapid, practical and useful aid for the diagnosis of PCA and also to assess disease activity. Patulous follicular openings are a specific dermoscopic sign of alopecia mucinosa. Lichen planopilaris is less common in China than in the West.
引用
收藏
页码:306 / 312
页数:7
相关论文
共 20 条
[1]   Scarring Alopecia [J].
Abal-Diaz, L. ;
Soria, X. ;
Casanova-Seuma, J. M. .
ACTAS DERMO-SIFILIOGRAFICAS, 2012, 103 (05) :376-387
[2]   Lichen Planopilaris: Update on Diagnosis and Treatment [J].
Assouly, Philippe ;
Reygagne, Pascal .
SEMINARS IN CUTANEOUS MEDICINE AND SURGERY, 2009, 28 (01) :3-10
[3]  
Chandrawansa P. H., 2003, SMJ Singapore Medical Journal, V44, P084
[4]   What's new in cicatricial alopecia? [J].
Dogra, Sunil ;
Sarangal, Rishu .
INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY, 2013, 79 (05) :576-590
[5]   PRIMARY CICATRICIAL ALOPECIAS: A REVIEW OF HISTOPATHOLOGIC FINDINGS IN 38 PATIENTS FROM A CLINICAL UNIVERSITY HOSPITAL IN SAO PAULO, BRAZIL [J].
Duarte Moure, Emanuella Rosyane ;
Romiti, Ricardo ;
da Matta Rivitti Machado, Maria Cecilia ;
Sakai Valente, Neusa Yuriko .
CLINICS, 2008, 63 (06) :747-752
[6]   Primary cicatricial alopecias: a UK survey [J].
Griffin, L. L. ;
Michaelides, C. ;
Griffiths, C. E. M. ;
Paus, R. ;
Harries, M. J. .
BRITISH JOURNAL OF DERMATOLOGY, 2012, 167 (03) :694-697
[7]   The Spectrum of Histopathological Lesions in Scarring Alopecia: A Prospective Study [J].
Kumar, Mahesh U. ;
Yelikar, Balasaheb Ramling .
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2013, 7 (07) :1372-1376
[8]   Dermoscopy guided scalp biopsy in cicatricial alopecia [J].
Miteva, M. ;
Tosti, A. .
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2013, 27 (10) :1299-1303
[9]   Alopecia areata investigational assessment guidelines - Part II [J].
Olsen, EA ;
Hordinsky, MK ;
Price, VH ;
Roberts, JL ;
Shapiro, J ;
Canfield, D ;
Duvic, M ;
King, LE ;
McMichael, AJ ;
Randall, VA ;
Turner, ML ;
Sperling, L ;
Whiting, DA ;
Norris, D .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2004, 51 (03) :440-447
[10]   Current and novel methods for assessing efficacy of hair growth promoters in pattern hair loss [J].
Olsen, EA .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2003, 48 (02) :253-262