Efficient and chemoselective conversion of carbonyl compounds to 1,3-dioxanes catalyzed with N-bromosuccinimide under almost neutral reaction conditions

被引：65
作者：
Karimi, B
Ebrahimian, GR
Seradj, H
机构：
[1] Inst Adv Studies Basic Sci, Dept Chem, Gava Zang, Zanjan, Iran
[2] Shiraz Univ Med Sci, Sch Pharm, Dept Chem & Med Chem, Shiraz 71345, Iran
来源：
ORGANIC LETTERS | 1999年 / 1卷 / 11期
关键词：
D O I：
10.1021/ol9909987
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] Various types of carbonyl compounds were converted to the corresponding 1,3-dioxanes in the presence of ethyl orthoformate, 1,3-propanediol, and a catalytic amount of NBS via an in situ acetal exchange process. In contrast to conventional acid-catalyzed acetalization reactions, acid sensitive substrates such as THP ethers and TBDMS ethers remain intact under described reaction conditions.
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页码：1737 / 1739
页数：3
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