Comparison of Enantiomeric Separations and Screening Protocols for Chiral Primary Amines by SFC and HPLC

被引：0
作者：
Woods, Ross M. [1 ]
Breitbach, Zachary S. [1 ]
Armstrong, Daniel W. [1 ,2 ]
机构：
[1] Univ Texas Arlington, Arlington, TX 76019 USA
[2] AZYP LLC, Arlington, TX USA
来源：
LC GC NORTH AMERICA | 2014年 / 32卷 / 09期
基金：
美国国家卫生研究院;
关键词：
SUPERCRITICAL-FLUID CHROMATOGRAPHY; GLYCOPEPTIDE STATIONARY PHASES; CROWN-ETHER; LIQUID-CHROMATOGRAPHY; COLUMN; CYCLOFRUCTANS; DERIVATIVES; RESOLUTION; DRUGS; ACIDS;
D O I：
暂无
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Supercritical (subcritical) fluid chromatography (SFC) was evaluated as an alternative to high performance liquid chromatography (HPLC) for the enantiomeric separation of primary amines on a cyclofructan-based chiral stationary phase. The effect of various organic modifiers, acidic and basic additives, as well as instrumentation-specific parameters such as column temperature, flow rate, and back pressure were evaluated. The results were compared to normal-phase and polar organic modes.
引用
收藏
页码：742 / 751
页数：10
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