An efficient enantioselective synthesis of (+)-(R,Z)-5-muscenone and (-)-(R)-muscone -: An example of a kinetic resolution and enantioconvergent transformation

被引：35

作者：

Fehr, C ^{[1
]}

Galindo, J ^{[1
]}

Etter, O ^{[1
]}

机构：

[1] Firmenich Co, Corp R&D Div, CH-1211 Geneva 8, Switzerland

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2004年 / 2004卷 / 09期

关键词：

enantioconvergence; kinetic resolution; macrocycles; odorants; reduction;

D O I：

10.1002/ejoc.200400037

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient catalytic kinetic resolution by CBS reduction and an original enantioconvergent transformation involving a Pd-II-catalyzed position-selective cyclization are the key steps for the synthesis of the exceptional musk odorant (R,Z)-5muscenone [(R)-1] and (R)-muscone [(R)-3]. (C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004).

引用

页码：1953 / 1957

页数：5

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