Site-selective Suzuki-Miyaura coupling of heteroaryl halides - understanding the trends for pharmaceutically important classes

被引：148
作者：
Almond-Thynne, Joshua [1 ]
Blakemore, David C. [2 ]
Pryde, David C. [2 ]
Spivey, Alan C. [1 ]
机构：
[1] Imperial Coll London, Dept Chem, South Kensington Campus, London SW7 2AZ, England
[2] Pfizer Worldwide Med Chem, Portway Bldg,Granta Pk, Cambridge CB21 6GS, England
来源：
CHEMICAL SCIENCE | 2017年 / 8卷 / 01期
关键词：
ONE-POT SYNTHESIS; BOND-DISSOCIATION ENERGIES; ESTROGEN-RECEPTOR LIGANDS; DINUCLEAR PD(I) COMPLEXES; ARYL BORONIC ACIDS; EFFICIENT SYNTHESIS; OXIDATIVE ADDITION; REDUCTIVE ELIMINATION; ARYLBORONIC ACIDS; METAL-COMPLEXES;
D O I：
10.1039/c6sc02118b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Suzuki-Miyaura cross-coupling reactions of heteroaryl polyhalides with aryl boronates are surveyed. Drawing on data from literature sources as well as bespoke searches of Pfizer's global chemistry RKB and CAS Scifinder (R) databases, the factors that determine the site-selectivity of these reactions are discussed with a view to rationalising the trends found.
引用
收藏
页码：40 / 62
页数：23
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