Emerging role of Fli1 in autoimmune diseases

被引：14
|
作者：
He, Yi-Sheng [1 ,2 ]
Yang, Xiao-Ke [3 ]
Hu, Yu-Qian [1 ,2 ]
Xiang, Kun [1 ,2 ]
Pan, Hai-Feng [1 ,2 ]
机构：
[1] Anhui Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China
[2] Inflammat & Immune Mediated Dis Lab Anhui Prov, 81 Meishan Rd, Hefei, Anhui, Peoples R China
[3] Anhui Med Univ, Dept Rheumatol & Immunol, Affiliated Hosp 1, 218 Jixi Rd, Hefei, Anhui, Peoples R China
来源：
INTERNATIONAL IMMUNOPHARMACOLOGY | 2021年 / 90卷
基金：
中国国家自然科学基金;
关键词：
Friend leukemia integration 1; Fli1; Autoimmune diseases; Autoimmunity; TRANSCRIPTION FACTOR FLI-1; SYSTEMIC-LUPUS-ERYTHEMATOSUS; TISSUE GROWTH-FACTOR; REGULATORY T-CELLS; ETS FAMILY; DEFICIENCY CONTRIBUTES; CYSTEINE CATHEPSINS; CHEMOATTRACTANT PROTEIN-1; POTENTIAL CONTRIBUTION; DERMAL FIBROBLASTS;
D O I：
10.1016/j.intimp.2020.107127
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The Ets transcription factor family exerts crucial role in cell proliferation, apoptosis, differentiation and migration. Friend leukemia integration 1 (Fli1), a member of the Ets family, is expressed in fibroblasts, endothelial cells and immune cells. Fli1 gene is participated in the development, proliferation, activation, migration and other processes of immune cells. Fli1 can also affect the function of immune cells by regulating cytokines and chemokines. Emerging evidence has shown that Fli1 is implicated in the etiology of several autoimmune diseases, including systemic sclerosis (SSc) and systemic lupus erythematosus (SLE). In this review, we mainly discuss the current evidence for the role of Fli1 in these diseases.
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收藏
页数：9
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