Hyperbaric oxygen as a treatment modality in cyclophosphamide-induced hemorrhagic cystitis

被引：8

作者：

Kaur, Dominder ^{[1
]}

Khan, Shakila P. ^{[2
,3
]}

Rodriguez, Vilmarie ^{[2
,3
]}

Arndt, Carola ^{[2
]}

Claus, Paul ^{[4
]}

机构：

[1] Nationwide Childrens Hosp, Div Hematol Oncol & BMT, Columbus, OH 43205 USA

[2] Mayo Clin, Div Pediat Hematol Oncol, Rochester, MN USA

[3] Mayo Clin, Div Pediat Hematol Oncol & Bone Marrow Transplant, Rochester, MN USA

[4] Mayo Clin, Div Hyperbar & Altitude Med, Rochester, MN USA

来源：

PEDIATRIC TRANSPLANTATION | 2018年 / 22卷 / 04期

关键词：

bone marrow transplant; cyclophosphamide; HC; HSCT; hyperbaric oxygen; pediatric; STEM-CELL TRANSPLANTATION; BONE-MARROW-TRANSPLANTATION; CLINICAL EFFECTIVENESS; RISK-FACTORS; THERAPY; INJURIES; CHILDREN; ASSOCIATION; MANAGEMENT; AGENTS;

D O I：

10.1111/petr.13171

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Late-onset HC is a well-recognized complication associated with cyclophosphamide/acrolein-induced toxicity. It poses a management challenge when hyperhydration and bladder irrigation do not result in clinical improvement as desired. The data regarding use of hyperbaric oxygen therapy (HBO2) as an early treatment modality in this clinical setting are limited. We present 2 cases, that were refractory to hyperhydration and bladder irrigation but responded to HBO2. They were treated with 20-30 daily sessions over weekdays with 100% oxygen for 90minutes at 2 atmospheric pressure units (2 atm). Both patients reported improved symptoms within the first 15 sessions, and hematuria diminished by 20 sessions. Hyperbaric oxygen is a less invasive, outpatient therapy that is effective for treatment of HC and is tolerated well by young patients.

引用

页数：4

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