6-(hydroxyphenyl)imidazo[2,1-b]thiazoles as potential antiinflammatory agents:: Effects on human neutrophil functions

被引：4
作者：
Andreani, A
Rambaldi, M
Leoni, A
Locatelli, A
Morigi, R
Traniello, S
Cariani, A
Rizzuti, O
Spisani, S
机构：
[1] Univ Bologna, Dept Pharmaceut Sci, I-40126 Bologna, Italy
[2] Univ Ferrara, Dept Biochem & Mol Biol, I-44100 Ferrara, Italy
来源：
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS | 2000年 / 65卷 / 02期
关键词：
phenols; antiinflammatory agents; imidazo[2,1-b]thiazoles; levamisole; NSAIDs; neutrophil functions;
D O I：
10.1135/cccc20000267
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Synthesis of 6-(hydroxyphenyl)imidazo [2,1-b]thiazoles related to levamisole from the corresponding methoxy derivatives is reported. These compounds were tested on in vitro neutrophil activation, namely locomotion induced by chemoattractants, superoxide generation and lysozyme degranulation triggered by agonists. These functions were evaluated after cell pulse with different concentrations of the drugs. Several derivatives showed significant inhibitory effects, in some cases more potent than the parent compound.
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收藏
页码：267 / 279
页数：13
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