From discovery to production: Scale-out of continuous flow meso reactors

被引:34
作者
Styring, Peter [1 ]
Parracho, Ana I. R. [1 ]
机构
[1] Univ Sheffield, Dept Chem & Proc Engn, Sheffield S1 3JD, S Yorkshire, England
基金
英国工程与自然科学研究理事会;
关键词
catalysis; continuous flow; Kumada reaction; parallel; scale-out; MINI-CONTINUOUS FLOW; MICRO REACTORS; ORGANIC HALIDES; NICKEL; COMPLEXES; CATALYSTS; REAGENTS; SYSTEM; BATCH;
D O I
10.3762/bjoc.5.29
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A continuous flow parallel reactor system has been developed to provide a rapid and seamless transition from the discovery phase and production phase of chemical synthesis, particularly in low volume-high value pharmaceuticals production. Using a single fixed bed catalytic meso reactor, reactions can be screened on a small discovery scale over short time scales. The intensified process produces sufficient material for a full analysis. By replication of the single reactor in parallel, the same chemistry can be achieved on a larger scale, on a small footprint and without the mass and heat transport limitations of reactor scale-out in batch.
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页数:10
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