The hope and the hype of organoid research

被引：284

作者：

Huch, Meritxell ^{[1
,2
,3
]}

Knoblich, Juergen A. ^{[4
]}

Lutolf, Matthias P. ^{[5
,6
,7
]}

Martinez-Arias, Alfonso ^{[8
]}

机构：

[1] Univ Cambridge, Wellcome Trust, Canc Res UK Gurdon Inst, Henry Wellcome Bldg Canc & Dev Biol,Tennis Court, Cambridge CB2 1QN, England

[2] Univ Cambridge, Wellcome Trust, Med Res Council Stem Cell Inst, Gleeson Bldg,Tennis Court Rd, Cambridge CB2 1QR, England

[3] Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge CB2 3DY, England

[4] Austrian Acad Sci, IMBA, Inst Mol Biotechnol, A-1030 Vienna, Austria

[5] Ecole Polytech Fed Lausanne, Sch Engn, CH-1015 Lausanne, Switzerland

[6] Ecole Polytech Fed Lausanne, Inst Bioengn, Sch Life Sci, CH-1015 Lausanne, Switzerland

[7] Ecole Polytech Fed Lausanne, Sch Basic Sci, Inst Chem Sci & Engn, CH-1015 Lausanne, Switzerland

[8] Univ Cambridge, Dept Genet, Downing Site, Cambridge CB2 3EH, England

来源：

DEVELOPMENT | 2017年 / 144卷 / 06期

基金：

欧盟地平线“2020”; 欧洲研究理事会; 英国生物技术与生命科学研究理事会; 英国惠康基金; 奥地利科学基金会;

关键词：

Disease modelling; Organoids; Stem cells; Therapies; IN-VITRO EXPANSION; STEM-CELLS; CEREBRAL ORGANOIDS; MOUSE; GENERATION; TISSUES; LIVER;

D O I：

10.1242/dev.150201

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The recent increase in organoid research has been met with great enthusiasm, as well as expectation, from the scientific community and the public alike. There is no doubt that this technology opens up a world of possibilities for scientific discovery in developmental biology as well as in translational research, but whether organoids can truly live up to this challenge is, for some, still an open question. In this Spotlight article, Meritxell Huch and Juergen Knoblich begin by discussing the exciting promise of organoid technology and give concrete examples of how this promise is starting to be realised. In the second part, Matthias Lutolf and Alfonso Martinez-Arias offer a careful and considered view of the state of the organoid field and its current limitations, and lay out the approach they feel is necessary to maximise the potential of organoid technology.

引用

页码：938 / 941

页数：4

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