Evaluation of molecules based on the electron donor-acceptor architecture as near-infrared β-amyloidal-targeting probes

被引：62

作者：

Fu, Hualong ^{[1
]}

Cui, Mengchao ^{[1
]}

Tu, Peiyu ^{[1
]}

Pan, Ziwei ^{[1
]}

Liu, Boli ^{[1
]}

机构：

[1] Beijing Normal Univ, Coll Chem, Key Lab Radiopharmaceut, Minist Educ, Beijing 100875, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 80期

关键词：

IN-VIVO DETECTION; ALZHEIMERS-DISEASE; FLUORESCENCE; DEPOSITS; PLAQUES; BINDING; DESIGN;

D O I：

10.1039/c4cc04907a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel class of near-infrared molecules based on the donor-acceptor architecture were synthesized and evaluated as A beta imaging probes. In vivo imaging studies suggested that MCAAD-3 could penetrate the blood-brain barrier and label Ab plaques in the brains of transgenic mice. Computational studies could reproduce the experimental trends well.

引用

收藏

页码：11875 / 11878

页数：4

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