Copper-catalyzed tandem N-arylation/condensation: synthesis of quinazolin-4(3H)-ones from 2-halobenzonitriles and amides

被引：37

作者：

Chai, Hongxin ^{[1
]}

Li, Jiarong ^{[1
]}

Yang, Liupan ^{[2
]}

Lu, Hongyan ^{[1
]}

Qi, Zhang ^{[1
]}

Shi, Daxin ^{[1
]}

机构：

[1] Beijing Inst Technol, Sch Chem Engn & Environm, Beijing 100081, Peoples R China

[2] Jiangsu Hengrui Med Co Ltd, Lianyungang Eco & Tech Dev Zone, Lianyungang 222047, Jiangsu, Peoples R China

来源：

RSC ADVANCES | 2014年 / 4卷 / 84期

关键词：

ONE-POT SYNTHESIS; MICROWAVE-ASSISTED SYNTHESIS; FACILE SYNTHESIS; OXIDATIVE SYNTHESIS; 4(3H)-QUINAZOLINONE DERIVATIVES; CARBONYLATIVE SYNTHESIS; PRIMARY ALCOHOLS; AQUEOUS-MEDIUM; QUINAZOLINONES; CYCLIZATION;

D O I：

10.1039/c4ra08031a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel, straightforward and practical copper-catalyzed domino protocol for synthesis of quinazolin-4(3H)-one derivatives from commercially available 2-halobenzonitriles and amides was successfully developed.

引用

页码：44811 / 44814

页数：4

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