Cellular regulation of ribonucleotide reductase in eukaryotes

被引：62

作者：

Guarino, Estrella ^{[1
]}

Salguero, Israel ^{[1
]}

Kearsey, Stephen E. ^{[1
]}

机构：

[1] Univ Oxford, Dept Zool, Oxford OX1 3PS, England

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2014年 / 30卷

基金：

英国生物技术与生命科学研究理事会;

关键词：

Deoxyribonucleotide pools; DNA synthesis; DNA repair; Genome stability; MITOCHONDRIAL-DNA REPLICATION; PHASE-SPECIFIC TRANSCRIPTION; DAMAGE CHECKPOINT PATHWAYS; FISSION YEAST; ESCHERICHIA-COLI; DNTP POOLS; UBIQUITIN LIGASE; INHIBITOR SML1; SUBCELLULAR-LOCALIZATION; SACCHAROMYCES-CEREVISIAE;

D O I：

10.1016/j.semcdb.2014.03.030

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Synthesis of deoxynucleoside triphosphates (dNTPs) is essential for both DNA replication and repair and a key step in this process is catalyzed by ribonucleotide reductases (RNRs), which reduce ribonucleotides (rNDPs) to their deoxy forms. Tight regulation of RNR is crucial for maintaining the correct levels of all four dNTPs, which is important for minimizing the mutation rate and avoiding genome instability. Although allosteric control of RNR was the first discovered mechanism involved in regulation of the enzyme, other controls have emerged in recent years. These include regulation of expression of RNR genes, proteolysis of RNR subunits, control of the cellular localization of the small RNR subunit, and regulation of RNR activity by small protein inhibitors. This review will focus on these additional mechanisms of control responsible for providing a balanced supply of dNTPs. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：97 / 103

页数：7

共 102 条

[1] Hypermutability and error catastrophe due to defects in ribonucleotide reductase [J].