Role of TGF-β1 in Human Colorectal Cancer and Effects after Cantharidinate Intervention

被引：7

作者：

Ma, Jie ^{[1
]}

Gao, Hai-Mei ^{[2
]}

Hua, Xin ^{[3
]}

Lu, Ze-Yuan ^{[4
]}

Gao, Hai-Cheng ^{[4
]}

机构：

[1] Jilin Univ, Dept Mol Med, Changchun 130023, Peoples R China

[2] Jilin Univ, Hosp 2, Dept Med Records, Changchun 130023, Peoples R China

[3] Jilin Univ, Hosp 3, Dept Cerebral Surg, Changchun 130023, Peoples R China

[4] Jilin Univ, Dept Clin Pharm & Pharmaceut Management, Changchun 130023, Peoples R China

来源：

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION | 2014年 / 15卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Colorectal cancer; TGF-beta; 1; cantharidinate;

D O I：

10.7314/APJCP.2014.15.9.4045

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Effects of transforming growth factor-beta (TGF-beta) were investigated in human colorectal cancer, and the influence of cantharidinate in inhibiting TGF-beta 1 expression was explored. Relationships among TGF-beta 1 and sex, age, tumor size, tumor location, tumor stage were also analyzed. H&E and immunohistochemistry staining were employed to assess colorectal cancer and TGF-beta 1 expression, respectively. Then, HCT-116 CRC cells were randomly divided into four groups, controls, no serum-treated, chemotherapy and cantharidinate-treated. Immunohistochemistry and real-time PCR were employed to assess the expression of TGF-beta 1 in CRC cells. Our data showed that the expression of TGF-beta 1 might be associated with tumor size and tumor location (P < 0.05). The expression of TGF-beta 1 in CRC groups was higher than in adjacent groups (P < 0.05). In addition, the expression of TGF-beta 1 in cantharidinate-treated group was much lower than in CRC group (P < 0.05). Taken together, these results suggest that TGF-beta 1 plays an important role in CRC development. Cantharidinate might inhibit the expression of TGF-beta 1 and control the development of colorectal cancer.

引用

页码：4045 / 4048

页数：4

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