A pooled-analysis of age and sex based coronary artery calcium scores percentiles

被引：16

作者：

de Ronde, Maurice W. J. ^{[1
,2
]}

Khoshiwal, Amir ^{[1
,2
]}

Planken, R. Nils ^{[3
]}

Boekholdt, S. Matthijs ^{[4
]}

Biemond, Mariette ^{[1
,2
]}

Budoff, Matthew J. ^{[5
]}

Cooil, Bruce ^{[6
]}

Lotufo, Paulo A. ^{[7
]}

Bensenor, Isabela M. ^{[7
]}

Ohmoto-Sekine, Yuki ^{[8
]}

Gudnason, Vilmundur ^{[9
]}

Aspelund, Thor ^{[9
]}

Gudmundsson, Elias Freyr ^{[9
]}

Zwinderman, Aeilko H. ^{[1
]}

Raggi, Paolo ^{[10
,11
]}

Pinto-Sietsma, Sara-Joan ^{[1
,2
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Vasc Med, Med Ctr, Meibergdreef 5, NL-1105 AZ Amsterdam, Netherlands

[2] Univ Amsterdam, Locat Acad Med Ctr, Dept Clin Epidemiol Biostat & Bioinformat, Med Ctr, Meibergdreef 5, NL-1105 AZ Amsterdam, Netherlands

[3] Univ Amsterdam, Locat Acad Med Ctr, Dept Radiol & Nucl Med, Med Ctr, Meibergdreef 5, NL-1105 AZ Amsterdam, Netherlands

[4] Univ Amsterdam, Locat Acad Med Ctr, Dept Cardiol, Med Ctr, Meibergdreef 5, NL-1105 AZ Amsterdam, Netherlands

[5] Harbor UCLA Angeles Biomed Res Inst, 1000 W Carson G, Torrance, CA 90509 USA

[6] Vanderbilt Univ, Owen Grad Sch Management, 2201 West End Ave, Nashville, TN 37235 USA

[7] Univ Sao Paulo, Dept Clin & Epidemiol Res, Rua Reitoria 374, BR-05508010 Sao Paulo, SP, Brazil

[8] Toranomon Gen Hosp, Hlth Management Ctr, Akasaka Interc AIR, Minato Ku, 107-0052 Tokyo5th Fl,1-8-1 Akasaka, Tokyo, Japan

[9] Iceland Heart Assoc, Holtasmari 1, Kopavogur, Iceland

[10] Univ Alberta, Dept Med, 11220 83 Ave NW, Edmonton, AB T6G 2J2, Canada

[11] Univ Alberta, Div Cardiol, 11220 83 Ave NW, Edmonton, AB T6G 2J2, Canada

来源：

JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY | 2020年 / 14卷 / 05期

关键词：

Coronary artery disease; Computed tomography; Calcium score; Percentile nomogram; ELECTRON-BEAM TOMOGRAPHY; RISK STRATIFICATION; CALCIFIED PLAQUE; HEART-DISEASE; GENDER; CT; ATHEROSCLEROSIS; REPRODUCIBILITY; QUANTIFICATION; CALCIFICATION;

D O I：

10.1016/j.jcct.2020.01.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Age and sex based coronary artery calcium score (CAC) percentiles have been used to improve coronary artery disease (CAD) risk prediction. However, the main limitation of the CACs percentiles currently in use is that they are often based on single studies. We performed a pooled analysis of all available studies that reported on CAC percentiles, in order to develop more generalizable age and sex nomograms. Methods: PubMed/Medline and Embase were searched for studies that reported nomograms of age and sex-based CACs percentiles. Studies were included if they reported data collected among asymptomatic individuals without a history of cardiovascular disease. Absolute CACs for each specific percentile stratum were pooled and new percentiles were generated taking into account the sample size of the study. Results: We found 831 studies, of which 12 met the inclusion criteria. Data on CACs percentiles of 134,336 Western and 33,488 Asians were pooled separately, rendering a weighted CACs percentile nomogram available at https://www.calciumscorecalculator.com Our weighted percentiles differed by up to 24% from the nomograms in use today. Conclusions: Our pooled age and sex based CACs percentiles based on over 155,000 individuals should provide a measure of risk that is more applicable to a wider population than the ones currently in use and hopefully will lead to better risk assessment and treatment decisions.

引用

页码：414 / 420

页数：7

共 32 条

[1]

Arnett DK, 2019, CIRCULATION, V140, pE563, DOI [10.1161/CIR.0000000000000677, 10.1016/j.jacc.2019.03.009, 10.1161/CIR.0000000000000678, 10.1016/j.jacc.2019.03.010]

[2] Coronary artery calcium measurement: Agreement of multirow detector and electron beam CP [J].

Becker, CR ;

Kleffel, T ;

Crispin, A ;

Knez, A ;

Young, J ;

Schoepf, UJ ;

Haberl, R ;

Reiser, MF .

AMERICAN JOURNAL OF ROENTGENOLOGY, 2001, 176 (05) :1295-1298

[3] Long-term prognosis associated with coronary calcification - Observations from a registry of 25,253 patients [J].

Budoff, Matthew J. ;

Shaw, Leslee J. ;

Liu, Sandy T. ;

Weinstein, Steven R. ;

Mosler, Tristen P. ;

Tseng, Philip H. ;

Flores, Ferdinand R. ;

Callister, Tracy Q. ;

Raggi, Paolo ;

Berman, Daniel S. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 49 (18) :1860-1870

[4] Coronary Calcium Predicts Events Better With Absolute Calcium Scores Than Age-Sex-Race/Ethnicity Percentiles MESA (Multi-Ethnic Study of Atherosclerosis) [J].

Budoff, Matthew J. ;

Nasir, Khurram ;

McClelland, Robyn L. ;

Detrano, Robert ;

Wong, Nathan ;

Blumenthal, Roger S. ;

Kondos, George ;

Kronmal, Richard A. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2009, 53 (04) :345-352

[5] Reproducibility of Coronary Artery Calcified Plaque with Cardiac 64-MDCT: The Multi-Ethnic Study of Atherosclerosis [J].

Budoff, Matthew Jay ;

McClelland, Robyn L. ;

Chung, Hyoju ;

Wong, Nathan D. ;

Carr, J. Jeffrey ;

Gray, Michael McNitt ;

Blumenthal, Roger S. ;

Detrano, Robert C. .

AMERICAN JOURNAL OF ROENTGENOLOGY, 2009, 192 (03) :613-617

[6] Coronary calcium measurements: Effect of CT scanner type and calcium measure on rescan reproducibility - MESA study [J].

Detrano, RC ;

Anderson, M ;

Nelson, J ;

Wong, ND ;

McNitt-Gray, M ;

Bild, DE .

RADIOLOGY, 2005, 236 (02) :477-484

[7] Coronary Risk Stratification, Discrimination, and Reclassification Improvement Based on Quantification of Subclinical Coronary Atherosclerosis The Heinz Nixdorf Recall Study [J].

Erbel, Raimund ;

Moehlenkamp, Stefan ;

Moebus, Susanne ;

Schmermund, Axel ;

Lehmann, Nils ;

Stang, Andreas ;

Dragano, Nico ;

Groenemeyer, Dietrich ;

Seibel, Rainer ;

Kaelsch, Hagen ;

Broecker-Preuss, Martina ;

Mann, Klaus ;

Siegrist, Johannes ;

Joeckel, Karl-Heinz .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2010, 56 (17) :1397-1406

[8] Effect of Naturally Random Allocation to Lower Low-Density Lipoprotein Cholesterol on the Risk of Coronary Heart Disease Mediated by Polymorphisms in NPC1L1, HMGCR, or Both [J].

Ference, Brian A. ;

Majeed, Faisal ;

Penumetcha, Raju ;

Flack, John M. ;

Brook, Robert D. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2015, 65 (15) :1552-1561

[9] 2013 ACC/AHA Guideline on the Assessment of Cardiovascular Risk A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines [J].

Goff, David C., Jr. ;

Lloyd-Jones, Donald M. ;

Bennett, Glen ;

Coady, Sean ;

D'Agostino, Ralph B. ;

Gibbons, Raymond ;

Greenland, Philip ;

Lackland, Daniel T. ;

Levy, Daniel ;

O'Donnell, Christopher J. ;

Robinson, Jennifer G. ;

Schwartz, J. Sanford ;

Shero, Susan T. ;

Smith, Sidney C., Jr. ;

Sorlie, Paul ;

Stone, Neil J. ;

Wilson, Peter W. F. .

CIRCULATION, 2014, 129 (25) :S49-S73

[10]

Grundy SM, 2019, J AM COLL CARDIOL, V73, P3168, DOI [10.1016/j.jacc.2018.11.002, 10.1016/j.jacc.2018.11.003, 10.1161/CIR.0000000000000625]

← 1 2 3 4 →