The tumor suppressor axis p53/miR-34a regulates Axl expression in B-cell chronic lymphocytic leukemia: implications for therapy in p53-defective CLL patients

被引：33

作者：

Boysen, J. ^{[1
]}

Sinha, S. ^{[1
]}

Price-Troska, T. ^{[1
]}

Warner, S. L. ^{[2
]}

Bearss, D. J. ^{[2
]}

Viswanatha, D. ^{[1
]}

Shanafelt, T. D. ^{[1
]}

Kay, N. E. ^{[1
]}

Ghosh, A. K. ^{[1
]}

机构：

[1] Mayo Clin, Div Hematol, Rochester, MN 55902 USA

[2] Tolero Pharmaceut Inc, Salt Lake City, UT USA

来源：

LEUKEMIA | 2014年 / 28卷 / 02期

关键词：

CPG METHYLATION; MIR-34A; APOPTOSIS; CANCER; P53; INACTIVATION; DELETION;

D O I：

10.1038/leu.2013.298

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：451 / 455

页数：6

共 15 条

[1]

Boysen J, 2011, ASH ANN M ABSTR, V118, P799

[2] Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis [J].

Chang, Tsung-Cheng ;

Wentzel, Erik A. ;

Kent, Oliver A. ;

Ramachandran, Kalyani ;

Mullendore, Michael ;

Lee, Kwang Hyuck ;

Feldmann, Georg ;

Yamakuchi, Munekazu ;

Ferlito, Marcella ;

Lowenstein, Charles J. ;

Arking, Dan E. ;

Beer, Michael A. ;

Maitra, Anirban ;

Mendell, Joshua T. .

MOLECULAR CELL, 2007, 26 (05) :745-752

[3] Epigenetic inactivation of the miR-34a in hematological malignancies [J].

Chim, C. S. ;

Wong, K. Y. ;

Qi, Y. ;

Loong, F. ;

Lam, W. L. ;

Wong, L. G. ;

Jin, D. Y. ;

Costello, J. F. ;

Liang, R. .

CARCINOGENESIS, 2010, 31 (04) :745-750

[4] 17p13/TP53 deletion in B-CLL patients is associated with microRNA-34a downregulation [J].

Dijkstra, M. K. ;

van Lom, K. ;

Tielemans, D. ;

Elstrodt, F. ;

Langerak, A. W. ;

van't Veer, M. B. ;

Jongen-Lavrencic, M. .

LEUKEMIA, 2009, 23 (03) :625-627

[5] The novel receptor tyrosine kinase Axl is constitutively active in B-cell chronic lymphocytic leukemia and acts as a docking site of nonreceptor kinases: implications for therapy [J].

Ghosh, Asish K. ;

Secreto, Charla ;

Boysen, Justin ;

Sassoon, Traci ;

Shanafelt, Tait D. ;

Mukhopadhyay, Debabrata ;

Kay, Neil E. .

BLOOD, 2011, 117 (06) :1928-1937

[6] The miR-34 family in cancer and apoptosis [J].

Hermeking, H. .

CELL DEATH AND DIFFERENTIATION, 2010, 17 (02) :193-199

[7] Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner [J].

Hirao, A ;

Cheung, A ;

Duncan, G ;

Girard, PM ;

Elia, AJ ;

Wakeham, A ;

Okada, H ;

Sarkissian, T ;

Wong, JA ;

Sakai, T ;

de Stanchina, E ;

Bristow, RG ;

Suda, T ;

Lowe, SW ;

Jeggo, PA ;

Elledge, SJ ;

Mak, TW .

MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (18) :6521-6532

[8] The role of prognostic factors in assessing 'high-risk' subgroups of patients with chronic lymphocytic leukemia [J].

Kay, N. E. ;

O'Brien, S. M. ;

Pettitt, A. R. ;

Stilgenbauer, S. .

LEUKEMIA, 2007, 21 (09) :1885-1891

[9] Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer [J].

Lodygin, Dmitri ;

Tarasov, Valery ;

Epanchintsev, Alexey ;

Berking, Carola ;

Knyazeva, Tatjana ;

Koerner, Henrike ;

Knyazev, Piotr ;

Diebold, Joachim ;

Hermeking, Heiko .

CELL CYCLE, 2008, 7 (16) :2591-2600

[10] Identification of the receptor tyrosine kinase AXL in breast cancer as a target for the human miR-34a microRNA [J].

Mackiewicz, Mark ;

Huppi, Konrad ;

Pitt, Jason J. ;

Dorsey, Tiffany H. ;

Ambs, Stefan ;

Caplen, Natasha J. .

BREAST CANCER RESEARCH AND TREATMENT, 2011, 130 (02) :663-679

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