Application of Fullerenes as Photosensitizers for Antimicrobial Photodynamic Inactivation: A Review

被引：24

作者：

Hou, Wenjia ^{[1
]}

Shi, Guorui ^{[1
]}

Wu, Songze ^{[2
]}

Mo, Jiayi ^{[1
]}

Shen, Lan ^{[1
]}

Zhang, Xiuqiang ^{[3
]}

Zhu, Yabin ^{[1
]}

机构：

[1] Ningbo Univ, Sch Med, Ningbo, Peoples R China

[2] Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Key Lab Marine Mat & Related Technol, Zhejiang Key Lab Marine Mat & Protect Technol, Ningbo, Peoples R China

[3] Affiliated Hosp Med Sch Ningbo Univ, Ningbo Key Lab Hearing & Balance Med, Ningbo, Peoples R China

来源：

FRONTIERS IN MICROBIOLOGY | 2022年 / 13卷

关键词：

antimicrobial photodynamic inactivation; photosensitizers; fullerene derivatives; antibacterial; multidrug resistance; functionalization; IN-VITRO; FUNCTIONALIZED FULLERENES; PHOTOPHYSICAL PROPERTIES; CATIONIC FULLERENE; WATER SUSPENSION; SINGLET OXYGEN; AMINO-ACID; THERAPY; C-60; BACTERIA;

D O I：

10.3389/fmicb.2022.957698

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Antimicrobial photodynamic inactivation (aPDI) is a newly emerged treatment approach that can effectively address the issue of multidrug resistance resulting from the overuse of antibiotics. Fullerenes can be used as promising photosensitizers (PSs) for aPDI due to the advantages of high triplet state yields, good photostability, wide antibacterial spectrum, and permissibility of versatile functionalization. This review introduces the photodynamic activities of fullerenes and the up-to-date understanding of the antibacterial mechanisms of fullerene-based aPDI. The most recent works on the functionalization of fullerenes and the application of fullerene derivatives as PSs for aPDI are also summarized. Finally, certain remaining challenges are emphasized to provide guidance on future research directions for achieving clinical application of fullerene-based aPDI.

引用

页数：14

共 121 条

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