The transcription factor Bhlhb4 is required for rod bipolar cell maturation

被引：90

作者：

Bramblett, DE ^{[1
]}

Pennesi, ME

Wu, SM

Tsai, MJ

机构：

[1] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Ophthalmol, Houston, TX 77030 USA

[3] Baylor Coll Med, Div Neurosci, Houston, TX 77030 USA

[4] Baylor Coll Med, Program Dev Biol, Houston, TX 77030 USA

来源：

NEURON | 2004年 / 43卷 / 06期

关键词：

D O I：

10.1016/j.neuron.2004.08.032

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Retinal bipolar cells are essential to the transmission of light information. Although bipolar cell dysfunction can result in blindness, little is known about the factors required for bipolar cell development and functional maturation. The basic helix-loop-helix (bHLH) transcription factor Bhlhb4 was found to be expressed in rod bipolar cells (RB). Electroretinograms (ERGS) in the adult Bhlhb4 knockout (Bhlhb4(-/-)) showed that the loss of Bhlhb4 resulted in disrupted rod signaling and profound retinal dysfunction resembling human congenital stationary night blindness (CSNB), characterized by the loss of the scotopic ERG b-wave. A depletion of inner nuclear layer (INL) cells in the adult Bhlhb4 knockout has been ascribed to the abolishment of the RB cell population during postnatal development. Other retinal cell populations including photoreceptors were unaltered. The timing of RB cell depletion in the Bhlhb4(-/-) mouse suggests that Bhlhb4 is essential for RB cell maturation.

引用

页码：779 / 793

页数：15

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