Effects of methomyl on lipid peroxidation and antioxidant enzymes in rat erythrocytes: In vitro studies

被引：45
|
作者：
Mansour, Sameeh A. [1 ]
Mossa, Abdel-Tawab H. [1 ]
Heikal, Tarek M. [1 ]
机构：
[1] NRC, ETRU, Dept Pesticide Chem, Cairo, Egypt
来源：
TOXICOLOGY AND INDUSTRIAL HEALTH | 2009年 / 25卷 / 08期
关键词：
antioxidant enzymes; erythrocytes; in vitro; lipid peroxidation; Methomyl; GLUTATHIONE S-TRANSFERASES; OXIDATIVE STRESS; MAMMALIAN BRAIN; DAMAGE; PESTICIDES; CARBOFURAN; ETHYL;
D O I：
10.1177/0748233709349829
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Erythrocytes are a convenient model to understand the membrane oxidative damage induced by various xenobiotic pro-oxidants. This study was designed to investigate the possibility of methomyl (Lannate (R) w 90% SP), S-methyl N-(methylcarbamoyloxy) thioacetimidate, to induce oxidative stress response in rat erythrocytes in vitro. Erythrocytes were incubated for 4 hours at 37 degrees C with different concentrations (0.0, 0.1, 0.5, 1.0, 1.5 and 2.0 mM) of methomyl. The results showed that methomyl decreased acetylcholinesterase (AChE), superoxide dismutase (SOD) and glutathione S-transferase (GST) activities and increased level of lipid peroxidation (LPO) as well as the percentage of haemolysis. The response occurred in a concentration-dependent manner. The study suggested that methomyl has the capability to induce oxidative damage as evidenced by increasing LPO and perturbations in various antioxidant enzymes.
引用
收藏
页码：557 / 563
页数：7
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