Microwave-Accelerated Iridium-Catalyzed Borylation of Aromatic C-H Bonds

被引：95

作者：

Harrisson, Peter ^{[1
]}

Morris, James ^{[2
]}

Marder, Todd B. ^{[1
]}

Steel, Patrick G. ^{[1
]}

机构：

[1] Univ Durham, Dept Chem, Durham DH1 3LE, England

[2] Syngenta Ltd, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 16期

基金：

英国工程与自然科学研究理事会;

关键词：

ONE-POT SYNTHESIS; 1,3-DISUBSTITUTED ARENES; ASSISTED REACTIONS; ORGANIC-SYNTHESIS; COMPLEXES; FUNCTIONALIZATION; PINACOLBORANE; DIBORON; ROUTE;

D O I：

10.1021/ol901306m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Microwave heating accelerates the Ir-catalyzed C-H borylation of aromatic substrates when compared with reactions carried out at the same temperature under standard heating conditions. Application to a one-pot single solvent process for tandem C-H borylation/Suzuki-Miyaura cross-coupling sequences using microwave-accelerated reactions gives fast and efficient access to a wide range of biaryl and heterobiaryl compounds.

引用

收藏

页码：3586 / 3589

页数：4

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