Probing the dynamics of prion diseases with amphotericin B

被引：24
作者：
Adjou, KT
Deslys, JP
Demaimay, R
Dormont, D
机构：
[1] Service de Neurovirologie, CEA/CRSSA, DSV/DRM, 92265 Fontenay aux Roses Cedex
来源：
TRENDS IN MICROBIOLOGY | 1997年 / 5卷 / 01期
关键词：
D O I：
10.1016/S0966-842X(97)81771-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Amphotericin B (AmB) is one of the rare drugs that affect the course of experimental prion diseases and modify the kinetics of abnormal prion protein accumulation in the central nervous system. Therefore, AmB could be used as a pharmacological tool to contribute to our understanding of the pathogenic mechanisms involved in these neurodegenerative disorders.
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页码：27 / 31
页数：5
相关论文
共 31 条
[1]   MS-8209, A NEW AMPHOTERICIN-B DERIVATIVE, PROVIDES ENHANCED EFFICACY IN DELAYING HAMSTER SCRAPIE [J].
ADJOU, KT ;
DEMAIMAY, R ;
LASMEZAS, C ;
DESLYS, JP ;
SEMAN, M ;
DORMONT, D .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (12) :2810-2812
[2]   Differential effects of a new amphotericin B derivative, MS-8209, on mouse BSE and scrapie: Implications for the mechanism of action of polyene antibiotics [J].
Adjou, KT ;
Demaimay, R ;
Lasmezas, CI ;
Seman, M ;
Deslys, JP ;
Dormont, D .
RESEARCH IN VIROLOGY, 1996, 147 (04) :213-218
[3]  
AMYX H, 1984, Neurology, V34, P149
[4]  
BOWLER WA, 1992, INFECT MED, V9, P17
[5]   A therapeutic panorama of the spongiform encephalopathies [J].
Brown, P. .
ANTIVIRAL CHEMISTRY & CHEMOTHERAPY, 1990, 1 (02) :75-83
[6]   PRECISE TARGETING OF THE PATHOLOGY OF THE SIALOGLYCOPROTEIN, PRP, AND VACUOLAR DEGENERATION IN MOUSE SCRAPIE [J].
BRUCE, ME ;
MCBRIDE, PA ;
FARQUHAR, CF .
NEUROSCIENCE LETTERS, 1989, 102 (01) :1-6
[7]   NORMAL DEVELOPMENT AND BEHAVIOR OF MICE LACKING THE NEURONAL CELL-SURFACE PRP PROTEIN [J].
BUELER, H ;
FISCHER, M ;
LANG, Y ;
BLUETHMANN, H ;
LIPP, HP ;
DEARMOND, SJ ;
PRUSINER, SB ;
AGUET, M ;
WEISSMANN, C .
NATURE, 1992, 356 (6370) :577-582
[8]  
Carp R. I., 1992, Neuropathogenic viruses and immunity., P111
[9]  
DEARMOND SJ, 1995, AM J PATHOL, V146, P785
[10]   PHARMACOLOGICAL STUDIES OF A NEW DERIVATIVE OF AMPHOTERICIN-B, MS-8209, IN MOUSE AND HAMSTER SCRAPIE [J].
DEMAIMAY, R ;
ADJOU, K ;
LASMEZAS, C ;
LAZARINI, F ;
CHERIFI, K ;
SEMAN, M ;
DESLYS, JP ;
DORMONT, D .
JOURNAL OF GENERAL VIROLOGY, 1994, 75 :2499-2503
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