Perivascular cells and tissue engineering: Current applications and untapped potential

被引：61

作者：

Avolio, Elisa ^{[1
]}

Alvino, Valeria V. ^{[1
]}

Ghorbel, Mohamed T. ^{[2
]}

Campagnolo, Paola ^{[3
]}

机构：

[1] Univ Bristol, Bristol Heart Inst, Div Expt Cardiovasc Med, Bristol BS8 1TH, Avon, England

[2] Univ Bristol, Bristol Heart Inst, Div Congenital Heart Surg, Bristol BS8 1TH, Avon, England

[3] Univ Surrey, Sch Biosci & Med, Guildford, Surrey, England

来源：

PHARMACOLOGY & THERAPEUTICS | 2017年 / 171卷

关键词：

Biomaterials; Pericytes; Perivascular cells; Tissue engineering; Vascular graft; Scaffold vascularization; PLURIPOTENT STEM-CELLS; MESENCHYMAL STROMAL CELLS; CULTURED VASCULAR CELLS; SMOOTH-MUSCLE-CELLS; FAT-STORING CELLS; ENDOTHELIAL-CELLS; BLOOD-VESSEL; IN-VIVO; PROGENITOR CELLS; SKELETAL-MUSCLE;

D O I：

10.1016/j.pharmthera.2016.11.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The recent development of tissue engineering provides exciting new perspectives for the replacement of failing organs and the repair of damaged tissues. Perivascular cells, including vascular smooth muscle cells, pericytes and other tissue specific populations residing around blood vessels, have been isolated from many organs and are known to participate to the in situ repair process and angiogenesis. Their potential has been harnessed for cell therapy of numerous pathologies; however, in this Review we will discuss the potential of perivascular cells in the development of tissue engineering solutions for healthcare. We will examine their application in the engineering of vascular grafts, cardiac patches and bone substitutes as well as other tissue engineering applications and we will focus on their extensive use in the vascularization of engineered constructs. Additionally, we will discuss the emerging potential of human pericytes for the development of efficient, vascularized and non immunogenic engineered constructs. (C) 2017 The Authors. Published by Elsevier Inc.

引用

页码：83 / 92

页数：10

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