Psoriasis and the TNF/IL23/IL17 axis

被引：86

作者：

Furue, Kazuhisa ^{[1
]}

Ito, Takamichi ^{[1
]}

Tsuji, Gaku ^{[1
]}

Kadono, Takafumi ^{[2
]}

Furue, Masutaka ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Dept Dermatol, Fukuoka, Fukuoka, Japan

[2] St Marianna Univ, Dept Dermatol, Sch Med, Kawasaki, Kanagawa, Japan

来源：

GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA | 2019年 / 154卷 / 04期

关键词：

Psoriasis; Tumor necrosis factor-alpha; Interleukin-23; Interleukin-17; INFLAMMATORY SKIN MARCH; IN-VIVO IMPLICATIONS; QUALITY-OF-LIFE; JAPANESE PATIENTS; PLAQUE PSORIASIS; ATOPIC-DERMATITIS; DENDRITIC CELLS; TH17; CYTOKINES; TREATMENT SATISFACTION; DOWN-REGULATION;

D O I：

10.23736/S0392-0488.18.06202-8

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The excellent response of psoriasis to anti-TNF-alpha(TNF)/IL23/IL17A biologics implies a crucial role for the TNF/IL23/IL17 axis in developing psoriasis. In addition to the TNF/IL23/IL17 axis provided by immune cells, current evidence points to an important contribution of TNF, IL23 and IL17C produced from non-hematopoietic keratinocytes. Therefore, crosstalk between immune cells and keratinocytes forms a multilayered feed-forward loop to accelerate the TNF/IL23/IL17A axis. Many biologics have already been licensed or are under clinical trials. Given that the IL-17 signature is more upregulated in the skin than in synovium in psoriatic arthritis, anti-IL-23/IL-17 agents seem to be superior to anti-TNF-alpha remedies in the treatment of skin lesions. In this review, we summarize recent topics in psoriasis and the TNF/IL23/IL17 axis.

引用

页码：418 / 424

页数：7

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