Transmission electron microscopic study of antibiotic action on Klebsiella pneumoniae biofilm

被引：45

作者：

Zahller, J

Stewart, PS

机构：

[1] Montana State Univ, Ctr Biofilm Engn, Bozeman, MT 59717 USA

[2] Montana State Univ, Dept Chem Engn, Bozeman, MT 59717 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 08期

关键词：

D O I：

10.1128/AAC.46.8.2679-2683.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The penetration of ampicillin and ciprofloxacin through biofilms formed by Klebsiella pneumoniae was confirmed by transmission electron microscopic observation of antibiotic-affected cells at the distal edge of the biofilm. Because the bacteria nevertheless survived antibiotic treatment, some protective mechanism other than inadequate penetration must have been at work in the biofilm.

引用

页码：2679 / 2683

页数：5

共 6 条

[1] Role of antibiotic penetration limitation in Klebsiella pneumoniae biofilm resistance to ampicillin and ciprofloxacin [J].