1,4-Naphthoquinone is a potent inhibitor of human cancer cell growth and angiogenesis

被引：62

作者：

Kayashima, Tomoko ^{[1
]}

Mori, Masaharu ^{[2
]}

Yoshida, Hiromi ^{[3
,4
]}

Mizushina, Yoshiyuki ^{[3
,4
]}

Matsubara, Kiminori ^{[1
,3
]}

机构：

[1] Hiroshima Univ, Dept Human Life Sci Educ, Grad Sch Educ, Hiroshima 7398524, Japan

[2] Okayama Prefectural Univ, Dept Nursing, Fac Hlth & Welf Sci, Okayama 7191197, Japan

[3] Kobe Gakuin Univ, Cooperat Res Ctr Life Sci, Nishi Ku, Kobe, Hyogo 6512180, Japan

[4] Kobe Gakuin Univ, Dept Nutr Sci, Lab Food & Nutr Sci, Kobe, Hyogo 6512180, Japan

来源：

CANCER LETTERS | 2009年 / 278卷 / 01期

关键词：

Angiogenesis; Human cancer cell; Aortic ring; Endothelial cell; 1,4-Naphthoquinone; HEPATOCELLULAR-CARCINOMA CELLS; CONVERTING ENZYME-INHIBITOR; NF-KAPPA-B; ENDOTHELIAL-CELLS; IN-VITRO; CAPILLARY GROWTH; DNA-POLYMERASE; COLLAGEN GEL; VITAMIN-K-2; SHIKONIN;

D O I：

10.1016/j.canlet.2008.12.020

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Angiogenesis inhibitors are beneficial for the prevention and treatment of angiogenesis-dependent diseases including cancer. Vitamin K2 and K3, which are naphthoquinone derivatives, inhibit angiogenesis. We examined the anti-cancer and anti-angiogenic effects of naphthoquinones and its structurally related compounds. Among these 13 compounds, 1,4-naphthoquinone strongly inhibited both human colon cancer cell (HCT116) growth and angiogenesis. To clarify the anti-angiogenic mechanism, the effects of 1,4-naphthoquinone on human umbilical vein endothelial cell (HUVEC) tube formation, proliferation and chemotaxis were examined. Consequently, 1,4-naphthoquinone inhibited HUVEC functions. These results suggest that 1,4-naphthoquinone may be useful to cancer therapy. (c) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：34 / 40

页数：7

共 27 条

[1] Antiangiogenic cancer therapy [J].

Cao, YH .

SEMINARS IN CANCER BIOLOGY, 2004, 14 (02) :139-145

[2] ANGIOGENESIS IN CANCER, VASCULAR, RHEUMATOID AND OTHER DISEASE [J].

FOLKMAN, J .

NATURE MEDICINE, 1995, 1 (01) :27-31

[3] Role of vitamin K2 in the development of hepatocellular carcinoma in women with viral cirrhosis of the liver [J].

Habu, D ;

Shiomi, S ;

Tamori, A ;

Takeda, T ;

Tanaka, T ;

Kubo, S ;

Nishiguchi, S .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2004, 292 (03) :358-361

[4] Shikonin circumvents cancer drug resistance by induction of a necroptotic death [J].

Han, Weidong ;

Li, Ling ;

Qiu, Shuang ;

Lu, Qinghua ;

Pan, Oiangrong ;

Gu, Ying ;

Luo, Jianhong ;

Hu, Xun .

MOLECULAR CANCER THERAPEUTICS, 2007, 6 (05) :1641-1649

[5]

Hisa T, 1998, ANTICANCER RES, V18, P783

[6] Anti-angiogenic activity of tocotrienol [J].

Inokuchi, H ;

Hirokane, H ;

Tsuzuki, T ;

Nakagawa, K ;

Igarashi, M ;

Miyazawa, T .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2003, 67 (07) :1623-1627

[7] Synergistic growth inhibition by acyclic retinoid and vitamin K2 in human hepatocellular carcinoma cells [J].

Kanamori, Toh ;

Shimizu, Masahito ;

Okuno, Masataka ;

Matsushima-Nishiwaki, Rie ;

Tsurumi, Hisashi ;

Kojima, Soichi ;

Moriwaki, Hisataka .

CANCER SCIENCE, 2007, 98 (03) :431-437

[8] Anti-tumor promoting effects of naphthoquinone derivatives on short term Epstein-Barr early antigen activation assay and in mouse skin carcinogenesis [J].

Kapadia, GJ ;

Balasubramanian, V ;

Tokuda, H ;

Konoshima, T ;

Takasaki, M ;

Koyama, J ;

Tagahaya, K ;

Nishino, H .

CANCER LETTERS, 1997, 113 (1-2) :47-53

[9]

KAWASAKI S, 1989, ACTA PATHOL JAPON, V39, P712

[10] The anti-angiogenic basis of metronomic chemotherapy [J].

Kerbel, RS ;

Kamen, BA .

NATURE REVIEWS CANCER, 2004, 4 (06) :423-436

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