Antioxidant vitamins in chronic renal failure

Reactive oxygen species (ROS) play a significant role in pathogenesis of chronic renal failure (CRF), leading to damage to protein, lipid and DNA. The present paper focuses on the extent of free radical damage on lipid (measured as malondialdehyde, MDA) and effect On antioxidant defense mechanism (measured as vitamin E and vitamin C in the serum of CRF patients predialytically. The study was done at M.S.Ramaiah Medical Teaching Hospital, Bangalore, between October 2005 to june 2006.40 cases and 40 controls between age group of 25 - 60 were taken. Lipid peroxidation was measured in terms of MDA and antioxidant were measured as vitamin E and Vitamin C in serum of CRF patients before dialysis. The level of MDA, creatinine, blood urea nitrogen was significantly increased, antioxidant vitamin levels were decreased in CRF patients as compared to normal subjects. The elevation of ROS can lead to lipid peroxidation with progressive renal failure and also promote the complication of CRF. These patients can be supplemented with antioxidant vitamins for preventing lipid peroxidation and occurance of complication. So, supplemention with antioxidant vitamins serves as a method of preventing oxidative stress among patients with renal disease.