NHERF1 Between Promises and Hopes: Overview on Cancer and Prospective Openings

被引：17

作者：

Centonze, Matteo ^{[1
]}

Saponaro, Concetta ^{[1
]}

Mangia, Anita ^{[1
]}

机构：

[1] IRCCS, Ist Tumori Giovanni Paolo II, Funct Biomorphol Lab, Bari, Italy

来源：

TRANSLATIONAL ONCOLOGY | 2018年 / 11卷 / 02期

关键词：

EXCHANGER REGULATORY FACTOR-1; BINDING PHOSPHOPROTEIN 50; TUMOR-INFILTRATING LYMPHOCYTES; CXCR2 MACROMOLECULAR COMPLEX; REDUCED EBP50 EXPRESSION; BREAST-CANCER; COLORECTAL-CANCER; PANCREATIC-CANCER; NUCLEAR NHERF1; PROTEIN NHERF1;

D O I：

10.1016/j.tranon.2018.01.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Na+/H+ exchanger regulatory factor 1 (NHERF1) is a scaffold protein, with two tandem PDZ domains and a carboxyl-terminal ezrin-binding (EB) region. This particular sticky structure is responsible for its interaction with different molecules to form multi-complexes that have a pivotal role in a lot of diseases. In particular, its involvement during carcinogenesis and cancer progression has been deeply analyzed in different tumors. The role of NHERF1 is not unique in cancer; its activity is connected to its subcellular localization. The literature data suggest that NHERF1 could be a new prognostic/predictive biomarker from breast cancer to hematological cancers. Furthermore, the high potential of this molecule as therapeutical target in different carcinomas is a new challenge for precision medicine. These evidences are part of a future view to improving patient clinical management, which should allow different tumor phenotypes to be treated with tailored therapies. This article reviews the biology of NHERF1, its engagement in different signal pathways and its involvement in different cancers, with a specific focus on breast cancer. It also considers NHERF1 potential role during inflammation related to most human cancers, designating new perspectives in the study of this "Janus-like" protein.

引用

页码：374 / 390

页数：17

共 158 条

[1] E6 and E7 from Human Papillomavirus Type 16 Cooperate To Target the PDZ Protein Na/H Exchange Regulatory Factor 1 [J].

Accardi, Rosita ;

Rubino, Rosa ;

Scalise, Mariafrancesca ;

Gheit, Tarik ;

Shahzad, Naveed ;

Thomas, Miranda ;

Banks, Lawrence ;

Indiveri, Cesare ;

Sylla, Bakary S. ;

Cardone, Rosa A. ;

Reshkin, Stephan J. ;

Tommasino, Massimo .

JOURNAL OF VIROLOGY, 2011, 85 (16) :8208-8216

[2] B7-H3 Expression in NSCLC and Its Association with B7-H4, PD-L1 and Tumor-Infiltrating Lymphocytes [J].

Altan, Mehmet ;

Pelekanou, Vasiliki ;

Schalper, Kurt A. ;

Toki, Maria ;

Gaule, Patricia ;

Syrigos, Konstantinos ;

Herbst, Roy S. ;

Rimm, David L. .

CLINICAL CANCER RESEARCH, 2017, 23 (17) :5202-5209

[3] RADIXIN IS A COMPONENT OF HEPATOCYTE MICROVILLI IN-SITU [J].

AMIEVA, MR ;

WILGENBUS, KK ;

FURTHMAYR, H .

EXPERIMENTAL CELL RESEARCH, 1994, 210 (01) :140-144

[4] Na+/H+ exchange in the tumour microenvironment: does NHE1 drive breast cancer carcinogenesis? [J].

Amith, Schammim R. ;

Fong, Sunny ;

Baksh, Shairaz ;

Fliegel, Larry .

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 2015, 59 (7-9) :367-377

[5] Regulation of G Protein-Coupled Receptor Function by Na+/H+ Exchange Regulatory Factors [J].

Ardura, Juan A. ;

Friedman, Peter A. .

PHARMACOLOGICAL REVIEWS, 2011, 63 (04) :882-900

[6] Immunohistochemical staining of radixin and moesin in prostatic adenocarcinoma [J].

Bartholow, Tanner L. ;

Chandran, Uma R. ;

Becich, Michael J. ;

Parwani, Anil V. .

BMC CLINICAL PATHOLOGY, 2011, 11

[7] The Carboxyl-terminal PDZ Ligand Motif of Chemokine Receptor CXCR2 Modulates Post-endocytic Sorting and Cellular Chemotaxis [J].

Baugher, Paige J. ;

Richmond, Ann .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (45) :30868-30878

[8] The scaffolding protein NHERF1 sensitizes EGFR-dependent tumor growth, motility and invadopodia function to gefitinib treatment in breast cancer cells [J].

Bellizzi, Antonia ;

Greco, Maria Raffaella ;

Rubino, Rosa ;

Paradiso, Angelo ;

Forciniti, Stefania ;

Zeeberg, Katrine ;

Cardone, Rosa Angela ;

Reshkin, Stephan Joel .

INTERNATIONAL JOURNAL OF ONCOLOGY, 2015, 46 (03) :1214-1224

[9] Na+/H+ exchanger regulatory factor 1 expression levels in blood and tissue predict breast tumour clinical behaviour [J].

Bellizzi, Antonia ;

Mangia, Anita ;

Malfettone, Andrea ;

Cardone, Rosa Angela ;

Simone, Giovanni ;

Reshkin, Stephan Joel ;

Paradiso, Angelo .

HISTOPATHOLOGY, 2011, 58 (07) :1086-1095

[10]

BERRYMAN M, 1993, J CELL SCI, V105, P1025

← 1 2 3 4 5 6 7 8 9 10 →