A tetramic acid derivative with protein tyrosine phosphatase 1B inhibitory activity and a new nortriterpene glycoside from the Indonesian marine sponge Petrosia sp.

被引：13

作者：

Maarisit, Wilmar ^{[1
,2
]}

Yamazaki, Hiroyuki ^{[1
]}

Kanno, Syu-ichi ^{[1
]}

Tomizawa, Ayako ^{[1
]}

Rotinsulu, Henki ^{[3
]}

Wewengkang, Defny S. ^{[3
]}

Sumilat, Deiske A. ^{[2
]}

Ukai, Kazuyo ^{[1
]}

Kapojos, Magie M. ^{[4
]}

Namikoshi, Michio ^{[1
]}

机构：

[1] Tohoku Med & Pharmaceut Univ, Fac Pharmaceut Sci, Sendai, Miyagi 9818558, Japan

[2] Sam Ratulangi Univ, Fac Fisheries & Marine Sci, Kampus Bahu, Manado 95115, Indonesia

[3] Sam Ratulangi Univ, Fac Math & Nat Sci, Kampus Bahu, Manado 95115, Indonesia

[4] Univ Pembangunan Indonesia, Fac Nursing, Bahu 95115, Manado, Indonesia

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2017年 / 27卷 / 04期

关键词：

Tetramic acid; Melophlin; Sarasinoside; Marine sponge; Petrosia sp; Protein tyrosine phosphatase 1B; NATURAL-PRODUCTS; MELOPHLUS-SARASSINORUM; ASTEROPUS-SARASINOSUM; DIABETES TREATMENT; OLIGOGLYCOSIDES; SAPONINS; TARGETS; CELLS; A1; C1;

D O I：

10.1016/j.bmcl.2016.12.077

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

During the search for protein tyrosine phosphatase 1B (PTP1B) inhibitors from marine organisms, the known tetramic acid derivative, melophlin C (1), was isolated as an active component together with the new nortriterpenoid saponin, sarasinoside S (2), and three homologues: sarasinosides A1 (3), I-1 (4), and J (5), from the Indonesian marine sponge Petrosia sp. The structure of 2 was elucidated on the basis of its spectroscopic data. Compound 1 inhibited PTP1B activity with an IC50 value of 14.6 mu M, while compounds 2-5 were not active at 15.2-16.0 mu M. This is the first study to report the inhibitory effects of a tetramic acid derivative on PTP1B activity. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：999 / 1002

页数：4

共 32 条

[31] A bromopyrrole-containing diterpene alkaloid from the Okinawan marine sponge Agelas nakamurai activates the insulin pathway in Huh-7 human hepatoma cells by inhibiting protein tyrosine phosphatase 1B
Yamazaki, Hiroyuki
Kanno, Syu-ichi
Abdjul, Delfly B.
Namikoshi, Michio
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 27 (10) : 2207 - 2209
[32] Synthesis and characterization of 2-(4-((1-alkyl or aryl-1H-1,2,3-triazol-4-yl)methoxy)phenyl)naphtho[1,2-d]oxazoles for protein tyrosine phosphatase 1B inhibitory activity
Madabhushi, Sridhar
Chinthala, Narsaiah
Kanwal, Abhinav
Kaur, Gagandeep
Banerjee, Sanjay K.
MEDICINAL CHEMISTRY RESEARCH, 2014, 23 (04) : 2062 - 2069

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