A tetramic acid derivative with protein tyrosine phosphatase 1B inhibitory activity and a new nortriterpene glycoside from the Indonesian marine sponge Petrosia sp.

被引：13

作者：

Maarisit, Wilmar ^{[1
,2
]}

Yamazaki, Hiroyuki ^{[1
]}

Kanno, Syu-ichi ^{[1
]}

Tomizawa, Ayako ^{[1
]}

Rotinsulu, Henki ^{[3
]}

Wewengkang, Defny S. ^{[3
]}

Sumilat, Deiske A. ^{[2
]}

Ukai, Kazuyo ^{[1
]}

Kapojos, Magie M. ^{[4
]}

Namikoshi, Michio ^{[1
]}

机构：

[1] Tohoku Med & Pharmaceut Univ, Fac Pharmaceut Sci, Sendai, Miyagi 9818558, Japan

[2] Sam Ratulangi Univ, Fac Fisheries & Marine Sci, Kampus Bahu, Manado 95115, Indonesia

[3] Sam Ratulangi Univ, Fac Math & Nat Sci, Kampus Bahu, Manado 95115, Indonesia

[4] Univ Pembangunan Indonesia, Fac Nursing, Bahu 95115, Manado, Indonesia

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2017年 / 27卷 / 04期

关键词：

Tetramic acid; Melophlin; Sarasinoside; Marine sponge; Petrosia sp; Protein tyrosine phosphatase 1B; NATURAL-PRODUCTS; MELOPHLUS-SARASSINORUM; ASTEROPUS-SARASINOSUM; DIABETES TREATMENT; OLIGOGLYCOSIDES; SAPONINS; TARGETS; CELLS; A1; C1;

D O I：

10.1016/j.bmcl.2016.12.077

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

During the search for protein tyrosine phosphatase 1B (PTP1B) inhibitors from marine organisms, the known tetramic acid derivative, melophlin C (1), was isolated as an active component together with the new nortriterpenoid saponin, sarasinoside S (2), and three homologues: sarasinosides A1 (3), I-1 (4), and J (5), from the Indonesian marine sponge Petrosia sp. The structure of 2 was elucidated on the basis of its spectroscopic data. Compound 1 inhibited PTP1B activity with an IC50 value of 14.6 mu M, while compounds 2-5 were not active at 15.2-16.0 mu M. This is the first study to report the inhibitory effects of a tetramic acid derivative on PTP1B activity. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：999 / 1002

页数：4

共 32 条

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Abdjul, Delfly B.
Yamazaki, Hiroyuki
Takahashi, Ohgi
Kirikoshi, Ryota
Mangindaan, Remy E. P.
Namikoshi, Michio
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (04) : 904 - 907
[2] New Hippolide Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Marine Sponge Hippospongia lachne
Piao, Shu-Juan
Jiao, Wei-Hua
Yang, Fan
Yi, Yang-Hua
Di, Ying-Tong
Han, Bing-Nan
Lin, Hou-Wen
MARINE DRUGS, 2014, 12 (07) : 4096 - 4109
[3] Sesquiterpene Hydroquinones with Protein Tyrosine Phosphatase 1B Inhibitory Activities from a Dysidea sp Marine Sponge Collected in Okinawa
Abdjul, Delfly B.
Yamazaki, Hiroyuki
Takahashi, Ohgi
Kirikoshi, Ryota
Ukai, Kazuyo
Namikoshi, Michio
JOURNAL OF NATURAL PRODUCTS, 2016, 79 (07): : 1842 - 1847
[4] Biphenyl ether derivatives with protein tyrosine phosphatase 1B inhibitory activity from the freshwater fungus Phoma sp.
Sumilat, Deiske A.
Yamazaki, Hiroyuki
Kanno, Syu-ichi
Saito, Ryo
Watanabe, Yuta
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JOURNAL OF ANTIBIOTICS, 2017, 70 (03) : 331 - 333
[5] Protein tyrosine phosphatase 1B inhibitory polybromobiphenyl ethers and monocyclofarnesol-type sesquiterpenes from the Indonesian marine sponge Lamellodysidea cf. herbacea
Kapojos, Magie M.
Abdjul, Delfly B.
Yamazaki, Hiroyuki
Kirikoshi, Ryota
Takahashi, Ohgi
Rotinsulu, Henki
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Sumilat, Deiske A.
Ukai, Kazuyo
Namikoshi, Michio
PHYTOCHEMISTRY LETTERS, 2018, 24 : 10 - 14
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Abdjul, Delfly B.
Yamazaki, Hiroyuki
Kanno, Syu-ichi
Wewengkang, Defny S.
Rotinsulu, Henki
Sumilat, Deiske A.
Ukai, Kazuyo
Kapojos, Magie M.
Namikoshi, Michio
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 27 (05) : 1159 - 1161
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Takahashi, Ohgi
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CHEMICAL & PHARMACEUTICAL BULLETIN, 2016, 64 (07) : 733 - 736
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Rotinsulu, Henki
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Wewengkang, Defny S.
Sumilat, Deiske A.
Namikoshi, Michio
JOURNAL OF ANTIBIOTICS, 2017, 70 (09) : 967 - 969
[9] α-Glucosidase and Protein Tyrosine Phosphatase 1B Inhibitory Activity of Plastoquinones from Marine Brown Alga Sargassum serratifolium
Ali, Md. Yousof
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Kim, Hyeung-Rak
Jung, Hyun Ah
Choi, Jae Sue
MARINE DRUGS, 2017, 15 (12):
[10] Isomalabaricane triterpenes with potent protein-tyrosine phosphatase 1B (PTP1B) inhibition from the Hainan sponge Stelletta sp.
Xue, Duo-Qing
Mao, Shui-Chun
Yu, Xiao-Qing
Guo, Yue-Wei
BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2013, 49 : 101 - 106

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