STUDY OF BACTERIA RESISTANCE MECHANISMS IN RESPONSE TO A STRESS INDUCED BY PHARMACEUTICALS COMPOUNDS

被引：1

作者：

Marthe, Logan ^{[1
]}

Stoica, Catalina ^{[2
]}

Chiriac, Laura Florentina ^{[2
]}

Galaon, Toma ^{[2
]}

Nita-Lazar, Mihai ^{[2
]}

机构：

[1] Univ Perpignan, Inst Univ Technol, Dept Genie Biol, Via Domitia, Perpignan, France

[2] Natl Res & Dev Inst Ind Ecol ECOIND Bucharest, 71-73 Drumul Podu Dambovitei, Bucharest 060652, Romania

来源：

20TH INTERNATIONAL SYMPOSIUM - THE ENVIRONMENT AND THE INDUSTRY (SIMI 2017) | 2017年

关键词：

biological adaptive markers; pharmaceutical compounds; gram-negative bacteria; defense mechanisms;

D O I：

10.21698/simi.2017.0038

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Three pharmaceutical compounds (Trimethoprim, Carbamazepine and Benzethonium chloride) were investigated to unveil possible toxic effects on two bacterial strains (Citrobacter freundii and Comamonas testosteroni). The pharmaceutical compounds stress triggered a bacterial defence mechanism which was evaluated at transcriptional and translational levels. In this study, potential bacterial biomarkers induced by the pharmaceutical stress were unraveled.

引用

页码：296 / 302

页数：7

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