Regulation of immune responses by E3 ubiquitin ligase Cbl-b

被引：69
作者：
Tang, Rong [1 ]
Langdon, Wallace Y. [2 ]
Zhang, Jian [3 ]
机构：
[1] Cent South Univ, Dept Nephrol, Xiangya Hosp, Changsha, Hunan, Peoples R China
[2] Univ Western Australia, Sch Biol Sci, Perth, WA, Australia
[3] Univ Iowa, Dept Pathol, Iowa City, IA 52242 USA
来源：
CELLULAR IMMUNOLOGY | 2019年 / 340卷
基金：
美国国家卫生研究院;
关键词：
Cbl-b; Ubiquitination; Innate and adaptive immune responses; T cell tolerance; Immune-related disorders; T-CELL DEVELOPMENT; NEGATIVE REGULATION; C-CBL; K33-LINKED POLYUBIQUITINATION; ACTIVATION THRESHOLD; CUTTING EDGE; BINDING-SITE; UBA DOMAINS; RING-TYPE; PROTEIN;
D O I：
10.1016/j.cellimm.2018.11.002
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Casitas B lymphoma-b (Cbl-b), a RING finger E3 ubiquitin ligase, has been identified as a critical regulator of adaptive immune responses. Cbl-b is essential for establishing the threshold for T cell activation and regulating peripheral T cell tolerance through various mechanisms. Intriguingly, recent studies indicate that Cbl-b also modulates innate immune responses, and plays a key role in host defense to pathogens and anti-tumor immunity. These studies suggest that targeting Cbl-b may represent a potential therapeutic strategy for the management of human immune-related disorders such as autoimmune diseases, infections, tumors, and allergic airway inflammation. In this review, we summarize the latest developments regarding the roles of Cbl-b in innate and adaptive immunity, and immune-mediated diseases.
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页数：9
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