Regulation of immune responses by E3 ubiquitin ligase Cbl-b

被引：69

作者：

Tang, Rong ^{[1
]}

Langdon, Wallace Y. ^{[2
]}

Zhang, Jian ^{[3
]}

机构：

[1] Cent South Univ, Dept Nephrol, Xiangya Hosp, Changsha, Hunan, Peoples R China

[2] Univ Western Australia, Sch Biol Sci, Perth, WA, Australia

[3] Univ Iowa, Dept Pathol, Iowa City, IA 52242 USA

来源：

CELLULAR IMMUNOLOGY | 2019年 / 340卷

基金：

美国国家卫生研究院;

关键词：

Cbl-b; Ubiquitination; Innate and adaptive immune responses; T cell tolerance; Immune-related disorders; T-CELL DEVELOPMENT; NEGATIVE REGULATION; C-CBL; K33-LINKED POLYUBIQUITINATION; ACTIVATION THRESHOLD; CUTTING EDGE; BINDING-SITE; UBA DOMAINS; RING-TYPE; PROTEIN;

D O I：

10.1016/j.cellimm.2018.11.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Casitas B lymphoma-b (Cbl-b), a RING finger E3 ubiquitin ligase, has been identified as a critical regulator of adaptive immune responses. Cbl-b is essential for establishing the threshold for T cell activation and regulating peripheral T cell tolerance through various mechanisms. Intriguingly, recent studies indicate that Cbl-b also modulates innate immune responses, and plays a key role in host defense to pathogens and anti-tumor immunity. These studies suggest that targeting Cbl-b may represent a potential therapeutic strategy for the management of human immune-related disorders such as autoimmune diseases, infections, tumors, and allergic airway inflammation. In this review, we summarize the latest developments regarding the roles of Cbl-b in innate and adaptive immunity, and immune-mediated diseases.

引用

页数：9

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