Microneedle Electrodes Toward an Amperometric GlucoseSensing Smart Patch

被引:83
作者
Invernale, Michael A. [1 ,2 ]
Tang, Benjamin C. [1 ,2 ]
York, Royce L. [1 ,2 ]
Le, Long [3 ]
Hou, David Yupeng [3 ]
Anderson, Daniel G. [1 ,2 ,3 ,4 ]
机构
[1] MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02142 USA
[2] Childrens Hosp, Dept Anesthesiol, Boston, MA 02115 USA
[3] MIT, Dept Chem Engn, Cambridge, MA 02139 USA
[4] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02142 USA
关键词
conducting polymers; glucose oxidase; glucose sensors; microneedles; DRUG-DELIVERY SYSTEM; TRANSDERMAL DELIVERY; MANAGEMENT; TRANSPORT; ARRAY;
D O I
10.1002/adhm.201300142
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Here, efforts toward the development of a microneedle-based glucose sensor or "smart patch" for intradermal glucose sensing are described. Metallic microneedle array electrodes, conducting polymers, and glucose oxidase form the sensor platform. This work represents the first steps toward the development of painless, transdermal-sensing devices for continuous glucose monitoring. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码:338 / 342
页数:5
相关论文
共 25 条
[1]  
Alva Shridhara, 2008, J Diabetes Sci Technol, V2, P546
[2]  
American Diabetes Association, 2012, DIAB STAT 2012
[3]   Microneedles: an emerging transdermal drug delivery system [J].
Bariya, Shital H. ;
Gohel, Mukesh C. ;
Mehta, Tejal A. ;
Sharma, Om Prakash .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 2012, 64 (01) :11-29
[4]   Materials for Diabetes Therapeutics [J].
Bratlie, Kaitlin M. ;
York, Roger L. ;
Invernale, Michael A. ;
Langer, Robert ;
Anderson, Daniel G. .
ADVANCED HEALTHCARE MATERIALS, 2012, 1 (03) :267-284
[5]   A high aspect ratio SU-8 fabrication technique for hollow microneedles for transdermal drug delivery and blood extraction [J].
Chaudhri, Buddhadev Paul ;
Ceyssens, Frederik ;
De Moor, Piet ;
Van Hoof, Chris ;
Puers, Robert .
JOURNAL OF MICROMECHANICS AND MICROENGINEERING, 2010, 20 (06)
[6]  
Chiu N.-F., 2005, P 2005 IEEE ENG MED
[7]   An electrically active microneedle array for electroporation [J].
Choi, Seong-O ;
Kim, Yeu Chun ;
Park, Jung-Hwan ;
Hutcheson, Joshua ;
Gill, Harvinder S. ;
Yoon, Yong-Kyu ;
Prausnitz, Mark R. ;
Allen, Mark G. .
BIOMEDICAL MICRODEVICES, 2010, 12 (02) :263-273
[8]  
Gilligan Barbara C, 2004, Diabetes Technol Ther, V6, P378, DOI 10.1089/152091504774198089
[9]   Fabrication and Testing of a Microneedles Sensor Array for p-Cresol Detection with Potential Biofuel Applications [J].
Harper, Jason C. ;
Brozik, Susan M. ;
Flemming, Jeb H. ;
McClain, Jaime L. ;
Polsky, Ronen ;
Raj, Dominic ;
Ten Eyck, Gregory A. ;
Wheeler, David R. ;
Achyuthan, Komandoor E. .
ACS APPLIED MATERIALS & INTERFACES, 2009, 1 (07) :1591-1598
[10]   Electrochemical glucose sensors and their applications in diabetes management [J].
Heller, Adam ;
Feldman, Ben .
CHEMICAL REVIEWS, 2008, 108 (07) :2482-2505