On DNA Packaging into Elastic Nanoparticles

被引：0

作者：

Li, Long

Wang, Jizeng ^{[1
]}

机构：

[1] Lanzhou Univ, Key Lab Mech Disaster & Environm Western China, Minist Educ, Lanzhou 730000, Gansu, Peoples R China

来源：

11TH INTERNATIONAL CONFERENCE OF NUMERICAL ANALYSIS AND APPLIED MATHEMATICS 2013, PTS 1 AND 2 (ICNAAM 2013) | 2013年 / 1558卷

基金：

中国国家自然科学基金;

关键词：

DNA packaging; Elasticity; Nanoparticle; Packaging force; BACTERIOPHAGE; EJECTION;

D O I：

10.1063/1.4825647

中图分类号：

O29 [应用数学];

学科分类号：

070104 ;

摘要：

In recent years, understanding the process of DNA packaging into elastic nanoparticles is of great interest to advancing practical applications in fields such as drug delivery, global ecology and bacterial pathogenicity. In this study, we adopt a unified continuum and statistical mechanics model by taking into account the effects of DNA bending, electrostatic repulsion between DNA-DNA strands and elastic deformation of the nanoparticles to quantitatively reveal the relation between packaging force, Young's modulus of the nanoparticles and DNA length packaged. We find that particle stiffness can significantly influence the ejection force when the particles are immersed in high electrostatic repulsion solution.

引用

页码：911 / 913

页数：3

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