Cognitive and Neuropsychiatric Profiles in Idiopathic Rapid Eye Movement Sleep Behavior Disorder and Parkinson's Disease

被引：17

作者：

Assogna, Francesca ^{[1
]}

Liguori, Claudio ^{[2
,3
]}

Cravello, Luca ^{[4
]}

Macchiusi, Lucia ^{[1
]}

Belli, Claudia ^{[5
]}

Placidi, Fabio ^{[2
,3
]}

Pierantozzi, Mariangela ^{[2
]}

Stefani, Alessandro ^{[2
]}

Mercuri, Bruno ^{[6
]}

Izzi, Francesca ^{[3
]}

Caltagirone, Carlo ^{[1
]}

Mercuri, Nicola B. ^{[1
,2
,3
]}

Pontieri, Francesco E. ^{[1
,7
]}

Spalletta, Gianfranco ^{[1
]}

Pellicano, Clelia ^{[1
]}

机构：

[1] IRCCS, Fdn Santa Lucia, I-00179 Rome, Italy

[2] Univ Tor Vergata, Dipartimento Med Sistemi, I-00133 Rome, Italy

[3] Univ Tor Vergata, Unita Neurol, Ctr Med Sonno, I-00133 Rome, Italy

[4] ASST Rhodense, Ctr Reg Alzheimer, I-20017 Rho, Italy

[5] Sapienza Univ Roma, Fac Med & Psicol, Dipartimento Psicol, I-00185 Rome, Italy

[6] Azienda Osped San Giovanni Addolorata, UOC Neurol, I-00184 Rome, Italy

[7] Sapienza Univ Roma, Dipartimento Neurosci Salute Mentale & Organi Sen, I-00189 Rome, Italy

来源：

JOURNAL OF PERSONALIZED MEDICINE | 2021年 / 11卷 / 01期

关键词：

neurodegeneration; risk factors; neuropsychiatry; anxiety; depression; DOPAMINE TRANSPORTER LEVELS; IMPAIRMENT; MEMORY; ALEXITHYMIA; DEPRESSION; SEVERITY; DEMENTIA; APATHY; RBD;

D O I：

10.3390/jpm11010051

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Rapid eye movement (REM) sleep behavior disorder (RBD) is a risk factor for developing Parkinson's disease (PD) and may represent its prodromal state. We compared neuropsychological and neuropsychiatric phenotypes of idiopathic (i) RBD, PD and healthy comparators (HC) in order to identify iRBD specific characteristics. Thirty-eight patients with iRBD, 38 PD patients with RBD (PD + RBD), 38 PD patients without RBD (PD-RBD) and 38 HC underwent a comprehensive neurological, neuropsychological and neuropsychiatric evaluation. iRBD, PD + RBD and PD-RBD performed worse than HC in short-term verbal memory, praxia, language and executive functions. iRBD had higher levels of anxiety, depression, apathy and alexithymia than HC. iRBD had higher levels of apathy than PD + RBD. Both PD groups had higher levels of anxiety and depression than HC. Surprisingly, iRBD performed better than all groups in long-term verbal memory. Patients diagnosed with iRBD are characterized by poor global cognitive performance, but better long-term memory and higher levels of depression, anxiety, alexithymia and apathy. Alexithymia and apathy in patients diagnosed with iRBD may be the expression of precocious derangement of emotional regulation, subsequently observed also in PD. Cognitive and neuropsychiatric symptoms of iRBD are early clinical manifestations of widespread neurodegeneration.

引用

页码：1 / 14

页数：14