A programmable 0.18-μm CMOS electrochemical sensor microarray for biomolecular detection

被引：81

作者：

Hassibi, Arjang ^{[1
]}

Lee, Thomas H. ^{[1
]}

机构：

[1] Stanford Univ, Ctr Integrated Syst, Stanford, CA 94305 USA

来源：

IEEE SENSORS JOURNAL | 2006年 / 6卷 / 06期

关键词：

biomedical transducers; biosensors; complementary metal-oxide-semiconductor (CMOS); technology; deoxyribonucleic acid (DNA) microarray; electrochemical analysis; electrodes; impedance spectroscopy; ion-sensitive field-effect transistor (ISFET); protein microarrays; voltammetry;

D O I：

10.1109/JSEN.2006.883904

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

A configurable electrochemical sensor microarray system-on-a-chip fabricated in a standard digital 0.18-mu m complementary metal-oxide-semiconductor (CMOS) process is presented. Each pixel within this 5 x 10 array occupies a 160 mu m x 120 mu m area and contains a differential electrochemical transducer with a programmable sensor. The sensor has a digitally configurable topology capable of performing different electroanalytical measurements for a variety of affinity-based biomolecular sensing applications. The main modes of operation for this system are impedance spectroscopy, voltammetry, potentiometry, and field-effect sensing.

引用

页码：1380 / 1388

页数：9

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