A programmable 0.18-μm CMOS electrochemical sensor microarray for biomolecular detection

被引:81
作者
Hassibi, Arjang [1 ]
Lee, Thomas H. [1 ]
机构
[1] Stanford Univ, Ctr Integrated Syst, Stanford, CA 94305 USA
关键词
biomedical transducers; biosensors; complementary metal-oxide-semiconductor (CMOS); technology; deoxyribonucleic acid (DNA) microarray; electrochemical analysis; electrodes; impedance spectroscopy; ion-sensitive field-effect transistor (ISFET); protein microarrays; voltammetry;
D O I
10.1109/JSEN.2006.883904
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
A configurable electrochemical sensor microarray system-on-a-chip fabricated in a standard digital 0.18-mu m complementary metal-oxide-semiconductor (CMOS) process is presented. Each pixel within this 5 x 10 array occupies a 160 mu m x 120 mu m area and contains a differential electrochemical transducer with a programmable sensor. The sensor has a digitally configurable topology capable of performing different electroanalytical measurements for a variety of affinity-based biomolecular sensing applications. The main modes of operation for this system are impedance spectroscopy, voltammetry, potentiometry, and field-effect sensing.
引用
收藏
页码:1380 / 1388
页数:9
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