Fatty acid composition of HDL phospholipids and coronary artery disease

被引:24
作者
Noori, Mohammad [1 ]
Darabi, Masoud [1 ]
Rahimipour, Ali [1 ]
Rahbani, Mohammad [1 ]
Abadi, Naser Aslan [2 ]
Darabi, Maryam [3 ]
Ghatrehsamani, Keyhan [1 ]
机构
[1] Tabriz Univ Med Sci, Sch Med, Dept Biochem, Tabriz, Iran
[2] Tabriz Univ Med Sci, Sch Med, Dept Cardiol, Tabriz, Iran
[3] Isfahan Univ, Sch Pharm & Pharmaceut Sci, Dept Biochem, Esfahan, Iran
关键词
CAD; Fatty acids; HDL composition; HIGH-DENSITY-LIPOPROTEIN; HEART-DISEASE; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; DOCOSAHEXAENOIC ACID; DIETARY-FAT; RISK; N-3; PLASMA; CHOLESTEROL;
D O I
10.1016/j.jacl.2008.11.010
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
BACKGROUND: The phospholipid fatty acid content of high-density lipoprotein (HDL) partially reflects that of the diet and has been reported to be associated with several important biological functions that might serve as risk markers for coronary heart disease. OBJECTIVE: To investigate whether fatty acid composition of HDL phospholipids correlates with angiographically documented coronary artery disease (CAD). METHODS: The population included 212 patients who underwent clinically indicated coronary angiography. The patients were classified with significantly diseased arteries (SDA) if one or more coronary arteries had a stenosis >50% and with minimally diseased arteries (NIDA) if there was no significant stenosis (<40%) in any artery. The severity of CAD was expressed by the number of affected vessels. The fatty acid composition of HDL phospholipids was determined by gas liquid chromatography. Multivariate analyses were used to test the independence of associations between the presence and severity of CAD as outcome variables and fatly acid composition of HDL phospholipids. RESULTS: Patients with SDA showed significantly lower levels of linoleic acid (P=.041), eicosapentaenoic acid (EPA) (P=.027), and docosahexaenoic acid (DHA) (P=.026) than patients with MDA in univariate analyses. The association of linoleic acid (odds ratio [OR].90, P<.05). EPA (OR, 0.41, P<.02), and DHA (OR, 0.48, P<.02) remained statistically significant in the multivariate analyses. The content of EPA (beta=-0.23, P<.01) and DHA (beta=-0.17, P<.05) remained inversely significantly associated with the severity of CAD. CONCLUSIONS: This study shows that polyunsaturated fatty acids. including EPA and DHA content of HDL particles, are independently associated with the presence and severity of angiographically documented CAD. 2009 National Lipid Association. All rights reserved.
引用
收藏
页码:39 / 44
页数:6
相关论文
共 28 条
  • [21] Dietary fat intake and risk of coronary heart disease in women: 20 years of follow-up of the nurses' health study
    Oh, K
    Hu, FB
    Manson, JE
    Stampfer, MJ
    Willett, WC
    [J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 2005, 161 (07) : 672 - 679
  • [22] Altered erythrocyte n-3 fatty acids in Mediterranean patients with coronary artery disease
    Paganelli, F
    Maixent, JM
    Duran, MJ
    Parhizgar, R
    Pieroni, G
    Sennoune, S
    [J]. INTERNATIONAL JOURNAL OF CARDIOLOGY, 2001, 78 (01) : 27 - 32
  • [23] Fatty acid composition of plasma, blood cells and whole blood:: Relevance for the assessment of the fatty acid status in humans
    Rise, P.
    Efigini, S.
    Ghezzi, S.
    Colli, S.
    Galli, C.
    [J]. PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 2007, 76 (06): : 363 - 369
  • [24] Evidence that phospholipids play a key role in pre-β apoA-I formation and high-density lipoprotein remodeling
    Rye, KA
    Duong, M
    Psaltis, MK
    Curtiss, LK
    Bonnet, DJ
    Stocker, R
    Barter, PJ
    [J]. BIOCHEMISTRY, 2002, 41 (41) : 12538 - 12545
  • [25] Association of the fatty acid composition of serum phospholipids with hemostatic factors
    Salomaa, VV
    Salminen, I
    Rasi, V
    Vahtera, E
    Aro, A
    Myllyla, G
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1997, 17 (05) : 809 - 813
  • [26] DIET, SERUM-CHOLESTEROL, AND DEATH FROM CORONARY HEART-DISEASE - THE WESTERN-ELECTRIC STUDY
    SHEKELLE, RB
    SHRYOCK, AM
    PAUL, O
    LEPPER, M
    STAMLER, J
    LIU, S
    RAYNOR, WJ
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1981, 304 (02) : 65 - 70
  • [27] Docosahexaenoic acid induces an anti-inflammatory profile in lipopolysaccharide-stimulated human THP-1 macrophages more effectively than eicosapentaenoic acid
    Weldon, Sinead M.
    Mullen, Anne C.
    Loscher, Christine E.
    Hurley, Lisa A.
    Roche, Helen M.
    [J]. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2007, 18 (04) : 250 - 258
  • [28] Anti-inflammatory effects of polyunsaturated fatty acids in THP-1 cells
    Zhao, GX
    Etherton, TD
    Martin, KR
    Heuvel, JPV
    Gillies, PJ
    West, SG
    Kris-Etherton, PM
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 336 (03) : 909 - 917