Structure-function relationships in telomerase genes

被引：47
作者：
Sykorova, Eva [1 ,2 ]
Fajkus, Jiri [1 ,2 ]
机构：
[1] Acad Sci Czech Republ, Inst Biophys, CZ-61265 Brno, Czech Republic
[2] Masaryk Univ, Dept Funct Genom & Prote, Inst Expt Biol, Fac Sci, CZ-61137 Brno, Czech Republic
来源：
BIOLOGY OF THE CELL | 2009年 / 101卷 / 07期
关键词：
alternative splicing; gene structure; telomerase; REVERSE-TRANSCRIPTASE HTERT; CATALYTIC SUBUNIT GENE; MITOCHONDRIAL-DNA DAMAGE; TETRAHYMENA TELOMERASE; MESSENGER-RNA; SPLICING PATTERNS; ENDOTHELIAL-CELLS; GENOME SEQUENCE; NUCLEAR TRANSLOCATION; TERMINAL TRANSFERASE;
D O I：
10.1042/BC20080205
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The TERT (telomerase reverse transcriptase) subunit of telomerase is an intensively studied macromolecule due to its key importance in maintaining genome integrity and role in cellular aging and cancer. In an effort to provide an up-to-date overview of the topic, we discuss the structure of TERT genes, their alternative splicing products and their functions. Nucleotide databases contain more than 90 full-length cDNA sequences of telomerase protein subunits. Numerous in silico, in vitro and in vivo experimental techniques have revealed a great deal of structural and functional data describing particular features of the telomerase subunit in various model organisms. We explore whether particular findings are generally applicable to telomerases or species-specific. We also discuss in an evolutionary context the role of identified functional TERT subdomains.
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收藏
页码：375 / 392
页数：18
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