Polyhydroxytriterpenoids and Phenolic Constituents from Forsythia suspensa (Thunb.) Vahl Leaves

被引：35

作者：

Ge, Ying ^{[1
]}

Wang, Yazhen ^{[5
]}

Chen, Pingping ^{[6
]}

Wang, Yufang ^{[1
]}

Hou, Congcong ^{[1
]}

Wu, Yibing ^{[1
]}

Zhang, Manli ^{[1
]}

Li, Ligeng ^{[1
]}

Huo, Changhong ^{[1
,2
]}

Shi, Qingwen ^{[1
,3
]}

Gao, Haixia ^{[4
]}

机构：

[1] Hebei Med Univ, Sch Pharmaceut Sci, Shijiazhuang 050017, Peoples R China

[2] Hebei Med Univ, Inst Chinese Integrat Med, Shijiazhuang 050017, Peoples R China

[3] Hebei Med Univ, Collaborat Innovat Ctr Forens Med Mol Identificat, Shijiazhuang 050017, Peoples R China

[4] Hebei Med Univ, Dept Pharmacol, Shijiazhuang 050017, Peoples R China

[5] Hebei Gen Hosp, Med Examinat Ctr, Shijiazhuang 050051, Peoples R China

[6] Hebei Univ Chinese Med, Shijiazhuang 050200, Peoples R China

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2016年 / 64卷 / 01期

关键词：

Forsythia suspensa (Thunb.) Vahl; leaves; triterpenoids; phenolics; antioxidant activity; antiproliferative activity; COROSOLIC ACID; TRITERPENOIDS;

D O I：

10.1021/acs.jafc.5b04509

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Forsythia suspensa (Thunb.) Vahl leaves have been consumed in China as a health-promoting functional tea for centuries. Three new polyhydroxytriterpenoid glycosides named suspensanosides A-C (1-3), seven known polyhydroxy-triterpenoids (4-10), and 12 known phenolics (11-22) were identified from F. suspensa leaves. Compounds 1-10, 15-17, and 22 have not been found in the Forsythia genus previously, whereas compound 14 was first reported to be isolated from the leaves of F. suspensa. All isolates were tested for their antiproliferative activities on BGC-823 and MCF-7 human tumor cell lines, whereas all phenolics were further investigated for their antioxidant activities by a DPPH assay. The results clearly demonstrate that triterpenoids, especially ursane-type triterpenoids, and the diverse phenolic components are crucial for the beneficial effects of F. suspensa leaves.

引用

页码：125 / 131

页数：7

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