Mitochondrial chaperones in cancer - From molecular biology to clinical diagnostics

被引：111
作者：
Czarnecka, Anna M.
Carnpanella, Claudia
Zummo, Giovanni
Cappello, Francesco
机构：
[1] Univ Palermo, Dept Expt Med, Human Anat Sect, I-90127 Palermo, Italy
[2] Warsaw Univ, Dept Genet, Warsaw, Poland
[3] Med Univ Warsaw, Postgrad Sch Mol Med, Warsaw, Poland
来源：
CANCER BIOLOGY & THERAPY | 2006年 / 5卷 / 07期
关键词：
Hsp60; Hsp10; mtHsp70; mortalin; prohibitin; cancer; mitochodnria;
D O I：
10.4161/cbt.5.7.2975
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Mitochondria are cell organelles involved in processes of cell life and death, and therefore also in tumoral transformation. Indeed, mitochondria dysfunction is a prominent feature of cancer cells. Mitochondrial proteins and DNA have also been previously studied as markers of tumorigenesis. Heat shock proteins (HSPs) are ubiquitous evolutionary conserved proteins. HSPs enhance their expression in stressed cells and they are involved in gene expression regulation, DNA replication, signal transcluction, differentiation, apoptosis, cellular senescence or immortalization. This review reflects recent views on the role of some mitochondrial molecular chaperones as prohibitin, mortalin and HSP60/HSP10 complex and their modifications leading to cell transformation and cancer development. These molecules could represent modern molecular biomarkers for oncological management.
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收藏
页码：714 / 720
页数：7
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