Schistosoma haematobium and Schistosomiasis mansoni: Production of an estradiol-related compound detected by elisa

被引：28

作者：

Botelho, M. C. ^{[1
,2
]}

Crespo, M. ^{[3
]}

Almeida, A. ^{[1
]}

Vieira, P. ^{[1
]}

Delgado, M. L. ^{[1
]}

Araujo, L. ^{[3
]}

Machado, J. C. ^{[2
,4
]}

Correia da Costa, J. M. ^{[1
]}

机构：

[1] Natl Inst Hlth, CIBP, P-4000055 Oporto, Portugal

[2] Univ Porto, Inst Pathol & Mol Immunol, IPATIMUP, Oporto, Portugal

[3] Portuguese Inst Oncol, Endocrinol Lab, Oporto, Portugal

[4] Univ Porto, Fac Med, P-4100 Oporto, Portugal

来源：

EXPERIMENTAL PARASITOLOGY | 2009年 / 122卷 / 03期

关键词：

Schistosomes; Estradiol; ELISA; ENDOTHELIAL-CELLS; HORMONES; 17-BETA-ESTRADIOL; RECEPTORS;

D O I：

10.1016/j.exppara.2009.04.001

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Estradiol is a steroid hormone secreted principally by the ovarian follicles in vertebrate animals. We have identified the production of an estradiol-related molecule in the trematodes Schistosoma haematobium and Schistosomiasis mansoni. We show in this work that this molecule related to estradiol is present in schistosome worm extracts. The detection method ELISA specific for estradiol, revealed the expression of this estradiol-related molecule in schistosome worm extracts, but not in Fasciola hepatica worm extracts. Our results demonstrate for the first time the production of an estradiol-related compound by a human parasite of the genus Schistosoma. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：250 / 253

页数：4

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